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Lekander M, Furst C, Rotstein S, et al. Does informed adjuvant placebo chemotherapy for breast-cancer elicit immune changes. Oncol Rep. 1994;1(4):699-703doi: 10.3892/or.1.4.699.
Lekander, M., Furst, C., Rotstein, S., Blomgren, H., & Fredrikson, M. (1994). Does informed adjuvant placebo chemotherapy for breast-cancer elicit immune changes. Oncology reports, 1(4), 699-703. https://doi.org/10.3892/or.1.4.699
Lekander, M, et al. "Does informed adjuvant placebo chemotherapy for breast-cancer elicit immune changes." Oncology reports vol. 1,4 (1994): 699-703. doi: https://doi.org/10.3892/or.1.4.699
Lekander M, Furst C, Rotstein S, Blomgren H, Fredrikson M. Does informed adjuvant placebo chemotherapy for breast-cancer elicit immune changes. Oncol Rep. 1994 Jul;1(4):699-703. doi: 10.3892/or.1.4.699. PMID: 21607425.
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Oncol Rep. 1994 Jul;1(4):699-703. doi: 10.3892/or.1.4.699.

Does informed adjuvant placebo chemotherapy for breast-cancer elicit immune changes.

Oncology reports

M Lekander, C Furst, S Rotstein, H Blomgren, M Fredrikson

Affiliations

  1. KAROLINSKA INST,DEPT CLIN NEUROSCI,STOCKHOLM,SWEDEN. KAROLINSKA HOSP,RADIUM HEMMET,DEPT GEN ONCOL,STOCKHOLM,SWEDEN. DANDERYD HOSP,DEPT GEN ONCOL,DANDERYD,SWEDEN. UPPSALA UNIV,DEPT CLIN PSYCHOL,UPPSALA,SWEDEN.

PMID: 21607425 DOI: 10.3892/or.1.4.699

Abstract

To study psychological effects on the immune system, a saline infusion was administered to 24 fully informed patients who previously had received adjuvant chemotherapy for breast cancer. Blood samples were drawn before and after treatment, and compared to samples obtained at home two days earlier. Patients displayed a rise in natural killer-cell activity and a tendency to lowered percentage of suppressor/cytotoxic cells when assessed before treatment as compared to at home. Trait anxiety was associated with numbers of leukocytes. It is concluded that immune status partly reflects psychological factors.

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