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Bioinformatics. 2011 Jun 15;27(12):1739-40. doi: 10.1093/bioinformatics/btr260. Epub 2011 May 05.

Molecular signatures database (MSigDB) 3.0.

Bioinformatics (Oxford, England)

Arthur Liberzon, Aravind Subramanian, Reid Pinchback, Helga Thorvaldsdóttir, Pablo Tamayo, Jill P Mesirov

Affiliations

  1. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

PMID: 21546393 PMCID: PMC3106198 DOI: 10.1093/bioinformatics/btr260

Abstract

MOTIVATION: Well-annotated gene sets representing the universe of the biological processes are critical for meaningful and insightful interpretation of large-scale genomic data. The Molecular Signatures Database (MSigDB) is one of the most widely used repositories of such sets.

RESULTS: We report the availability of a new version of the database, MSigDB 3.0, with over 6700 gene sets, a complete revision of the collection of canonical pathways and experimental signatures from publications, enhanced annotations and upgrades to the web site.

AVAILABILITY AND IMPLEMENTATION: MSigDB is freely available for non-commercial use at http://www.broadinstitute.org/msigdb.

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