Display options
Share it on

Nucleic Acids Res. 2011 Jul;39:W412-5. doi: 10.1093/nar/gkr313. Epub 2011 May 05.

iPath2.0: interactive pathway explorer.

Nucleic acids research

Takuji Yamada, Ivica Letunic, Shujiro Okuda, Minoru Kanehisa, Peer Bork

Affiliations

  1. EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany.

PMID: 21546551 PMCID: PMC3125749 DOI: 10.1093/nar/gkr313

Abstract

iPath2.0 is a web-based tool (http://pathways.embl.de) for the visualization and analysis of cellular pathways. Its primary map summarizes the metabolism in biological systems as annotated to date. Nodes in the map correspond to various chemical compounds and edges represent series of enzymatic reactions. In two other maps, iPath2.0 provides an overview of secondary metabolite biosynthesis and a hand-picked selection of important regulatory pathways and other functional modules, allowing a more general overview of protein functions in a genome or metagenome. iPath2.0's main interface is an interactive Flash-based viewer, which allows users to easily navigate and explore the complex pathway maps. In addition to the default pre-computed overview maps, iPath offers several data mapping tools. Users can upload various types of data and completely customize all nodes and edges of iPath2.0's maps. These customized maps give users an intuitive overview of their own data, guiding the analysis of various genomics and metagenomics projects.

References

  1. BMC Bioinformatics. 2003 Sep 11;4:41 - PubMed
  2. Nat Protoc. 2007;2(10):2366-82 - PubMed
  3. Science. 2011 Feb 4;331(6017):555-61 - PubMed
  4. Nature. 2010 Mar 4;464(7285):59-65 - PubMed
  5. Trends Biochem Sci. 2008 Mar;33(3):101-3 - PubMed
  6. Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1374-9 - PubMed
  7. Nucleic Acids Res. 2010 Jan;38(Database issue):D355-60 - PubMed
  8. DNA Res. 2007 Aug 31;14(4):169-81 - PubMed
  9. Nucleic Acids Res. 2011 Jan;39(Database issue):D561-8 - PubMed
  10. Nucleic Acids Res. 2010 Jan;38(Database issue):D190-5 - PubMed
  11. PLoS One. 2009 Nov 11;4(11):e7710 - PubMed
  12. Bioinformatics. 2010 Dec 1;26(23):2977-8 - PubMed
  13. Science. 2006 Jun 2;312(5778):1355-9 - PubMed
  14. Science. 2010 Jan 15;327(5963):343-8 - PubMed
  15. Nat Biotechnol. 2010 Jan;28(1):57-63 - PubMed
  16. Bioinformatics. 2007 Jan 1;23(1):127-8 - PubMed
  17. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W423-6 - PubMed

Substances

MeSH terms

Publication Types