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Gopal V, Bhadbhade M, Chan DS, et al. 2-Bromo-5,7-dimeth-oxy-4-phenyl-quinoline. Acta Crystallogr Sect E Struct Rep Online. 2009;65:o635doi: 10.1107/S160053680900587X.
Gopal, V., Bhadbhade, M., Chan, D. S., Leu, C. W., Black, D. S., & Kumar, N. (2009). 2-Bromo-5,7-dimeth-oxy-4-phenyl-quinoline. Acta crystallographica. Section E, Structure reports online, 65o635. https://doi.org/10.1107/S160053680900587X
Gopal, Veshal, et al. "2-Bromo-5,7-dimeth-oxy-4-phenyl-quinoline." Acta crystallographica. Section E, Structure reports online vol. 65 (2009): o635. doi: https://doi.org/10.1107/S160053680900587X
Gopal V, Bhadbhade M, Chan DS, Leu CW, Black DS, Kumar N. 2-Bromo-5,7-dimeth-oxy-4-phenyl-quinoline. Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 28;65:o635. doi: 10.1107/S160053680900587X. PMID: 21582284; PMCID: PMC2968525.
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Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 28;65:o635. doi: 10.1107/S160053680900587X.

2-Bromo-5,7-dimeth-oxy-4-phenyl-quinoline.

Acta crystallographica. Section E, Structure reports online

Veshal Gopal, Mohan Bhadbhade, Daniel Shiu Hin Chan, Chao-Wei Leu, David Stc Black, Naresh Kumar

PMID: 21582284 PMCID: PMC2968525 DOI: 10.1107/S160053680900587X

Abstract

The title compound, C(17)H(14)BrNO(2), was synthesized by the treatment of 5,7-dimeth-oxy-4-phenyl-quinolin-2-one with phosphoryl bromide in a Vilsmeier-type reaction. There are two independent mol-ecules (A and B) in the asymmetric unit which differ by 11.2° in the orientation of the 4-phenyl ring with respect to the planar quinoline ring system [dihedral angles = 55.15 (8) and 66.34 (8)° in mol-ecules A and B, respectively]. In the crystal structure, the independent mol-ecules are linked via C-H⋯N and C-H⋯O hydrogen bonds, forming centrosymmetric tetra-meric units which are cross-linked through C-H⋯π and C-Br⋯π inter-actions with Br⋯centroid distances of 3.4289 (8) and 3.5967 (8) Å.

References

  1. J Med Chem. 2002 Jun 6;45(12):2543-55 - PubMed
  2. Acta Crystallogr A. 2008 Jan;64(Pt 1):112-22 - PubMed

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