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Database (Oxford). 2011 May 23;2011:bar018. doi: 10.1093/database/bar018. Print 2011.

Data mining using the Catalogue of Somatic Mutations in Cancer BioMart.

Database : the journal of biological databases and curation

Rebecca Shepherd, Simon A Forbes, David Beare, S Bamford, Charlotte G Cole, Sari Ward, Nidhi Bindal, Prasad Gunasekaran, Mingming Jia, Chai Yin Kok, Kenric Leung, Andrew Menzies, Adam P Butler, Jon W Teague, Peter J Campbell, Michael R Stratton, P Andrew Futreal

Affiliations

  1. Cancer Genome Project, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.

PMID: 21609966 PMCID: PMC3263736 DOI: 10.1093/database/bar018

Abstract

Catalogue of Somatic Mutations in Cancer (COSMIC) (http://www.sanger.ac.uk/cosmic) is a publicly available resource providing information on somatic mutations implicated in human cancer. Release v51 (January 2011) includes data from just over 19,000 genes, 161,787 coding mutations and 5573 gene fusions, described in more than 577,000 tumour samples. COSMICMart (COSMIC BioMart) provides a flexible way to mine these data and combine somatic mutations with other biological relevant data sets. This article describes the data available in COSMIC along with examples of how to successfully mine and integrate data sets using COSMICMart. DATABASE URL: http://www.sanger.ac.uk/genetics/CGP/cosmic/biomart/martview/.

References

  1. Curr Protoc Hum Genet. 2008 Apr;Chapter 10:Unit 10.11 - PubMed
  2. Science. 2008 Sep 26;321(5897):1807-12 - PubMed
  3. Methods Mol Biol. 2011;696:93-105 - PubMed
  4. Nature. 2010 Apr 15;464(7291):993-8 - PubMed
  5. Nucleic Acids Res. 2009 Jul;37(Web Server issue):W23-7 - PubMed
  6. Hum Mutat. 2007 Jun;28(6):622-9 - PubMed
  7. Nat Rev Cancer. 2010 Apr;10(4):241-53 - PubMed
  8. Nature. 2008 Oct 23;455(7216):1061-8 - PubMed
  9. Genome Res. 2002 Oct;12(10):1599-610 - PubMed
  10. Nat Rev Drug Discov. 2009 Sep;8(9):709-23 - PubMed
  11. Hum Mutat. 2000;15(1):7-12 - PubMed
  12. Nucleic Acids Res. 2009 Jan;37(Database issue):D211-5 - PubMed
  13. Science. 2006 Oct 13;314(5797):268-74 - PubMed
  14. Nucleic Acids Res. 2010 Jan;38(Database issue):D652-7 - PubMed
  15. Methods Enzymol. 2008;438:331-41 - PubMed
  16. Nature. 2008 Oct 23;455(7216):1069-75 - PubMed
  17. Nucleic Acids Res. 2011 Jan;39(Database issue):D691-7 - PubMed
  18. Nucleic Acids Res. 2010 Jan;38(Database issue):D557-62 - PubMed
  19. Nucleic Acids Res. 2010 Jan;38(Database issue):D142-8 - PubMed

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