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Lease KA, Papageorgio C. Bioinformatic prediction of ultraviolet light mutagenesis sensitivity of human genes and a method for genetically engineering UVB resistance. Cancer Inform. 2011;10:121-31doi: 10.4137/CIN.S6670.
Lease, K. A., & Papageorgio, C. (2011). Bioinformatic prediction of ultraviolet light mutagenesis sensitivity of human genes and a method for genetically engineering UVB resistance. Cancer informatics, 10121-31. https://doi.org/10.4137/CIN.S6670
Lease, Kevin A, and Papageorgio, Chris. "Bioinformatic prediction of ultraviolet light mutagenesis sensitivity of human genes and a method for genetically engineering UVB resistance." Cancer informatics vol. 10 (2011): 121-31. doi: https://doi.org/10.4137/CIN.S6670
Lease KA, Papageorgio C. Bioinformatic prediction of ultraviolet light mutagenesis sensitivity of human genes and a method for genetically engineering UVB resistance. Cancer Inform. 2011 Apr 18;10:121-31. doi: 10.4137/CIN.S6670. PMID: 21584265; PMCID: PMC3091412.
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Cancer Inform. 2011 Apr 18;10:121-31. doi: 10.4137/CIN.S6670.

Bioinformatic prediction of ultraviolet light mutagenesis sensitivity of human genes and a method for genetically engineering UVB resistance.

Cancer informatics

Kevin A Lease, Chris Papageorgio

Affiliations

  1. Department of Internal Medicine, Education Office, One Hospital Drive, MA419, University of Missouri 65212, USA.

PMID: 21584265 PMCID: PMC3091412 DOI: 10.4137/CIN.S6670

Abstract

Living on earth, we are exposed to ultraviolet (UV) light as part of the solar radiation. UVB spectrum light exposure contributes to the development of skin cancer by interacting with pyrimidine pairs to create lesions called cyclobutane pyrimidine dimers. If these lesions are not removed by nucleotide excision repair, they often give rise to C to T transition mutations. Based on these observations, a bioinformatics approach was used to predict the vulnerability of human protein coding genes to UVB induced loss of function mutations. This data was used to evaluate in depth those genes associated with malignant melanoma. In addition, we demonstrate a method of genetically engineering genes that significantly improves resistance to UVB loss of function mutations.

Keywords: melanoma; mutagenesis; skin cancer; ultraviolet light

References

  1. J Invest Dermatol. 2008 Apr;128(4):980-7 - PubMed
  2. J Invest Dermatol. 2001 Aug;117(2):294-300 - PubMed
  3. Oncology (Williston Park). 2009 May;23(6):488-96 - PubMed
  4. J Biol Chem. 1996 Jul 5;271(27):15942-9 - PubMed
  5. Cancer Lett. 2006 Jul 18;238(2):168-79 - PubMed
  6. Nature. 2001 Jan 11;409(6817):207-11 - PubMed
  7. J Intern Med. 2002 Jul;252(1):1-10 - PubMed
  8. Nat Med. 1998 Feb;4(2):232-4 - PubMed
  9. Annu Rev Pathol. 2009;4:551-79 - PubMed
  10. J Natl Cancer Inst. 2000 Jun 21;92(12):1006-10 - PubMed
  11. FASEB J. 2006 Sep;20(11):1927-9 - PubMed
  12. J Clin Oncol. 2006 Sep 10;24(26):4340-6 - PubMed
  13. Expert Rev Dermatol. 2009 Apr 1;4(2):131 - PubMed
  14. Arch Dermatol. 2001 Nov;137(11):1477-85 - PubMed
  15. Cell Mol Life Sci. 2009 Mar;66(6):994-1009 - PubMed
  16. Ann Intern Med. 2009 Feb 3;150(3):194-8 - PubMed
  17. Cancer Cell. 2007 Jul;12(1):9-22 - PubMed
  18. Clin Exp Metastasis. 2003;20(6):531-9 - PubMed
  19. Nat Biotechnol. 2004 Aug;22(8):1035-6 - PubMed
  20. Nature. 2002 Jun 27;417(6892):949-54 - PubMed
  21. Am J Hum Genet. 2002 Apr;70(4):829-44 - PubMed
  22. Int J Cancer. 1998 Feb 20;79(1):91-5 - PubMed
  23. Cell Signal. 2002 May;14(5):381-95 - PubMed
  24. Nat Genet. 1999 Jul;22(3):231-8 - PubMed
  25. Genome Biol. 2004;5(10):R80 - PubMed
  26. Cancer Res. 2004 Oct 1;64(19):7002-10 - PubMed
  27. Mol Biol Cell. 1992 Feb;3(2):197-209 - PubMed
  28. Trends Cell Biol. 2008 Apr;18(4):157-64 - PubMed
  29. Mutat Res. 2005 Apr 1;571(1-2):19-31 - PubMed
  30. Dermatol Clin. 2007 Oct;25(4):541-57, viii-ix - PubMed
  31. J Investig Dermatol Symp Proc. 1999 Sep;4(1):6-10 - PubMed
  32. Exp Dermatol. 2010 Jul 1;19(7):617-27 - PubMed
  33. Trends Biochem Sci. 2010 Dec;35(12):660-8 - PubMed
  34. Nature. 2005 Jul 7;436(7047):117-22 - PubMed
  35. Nature. 2000 Nov 16;408(6810):307-10 - PubMed
  36. Mol Biol Cell. 1997 Feb;8(2):287-301 - PubMed

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