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Hemmer J, Krause H, Thein T, et al. Comparison of flow cytometric DNA content in the primary tumor and in the corresponding lymph-node metastasis of patients with squamous cells carcinomas of the head and neck. Int J Oncol. 1992;1(5):551-3doi: 10.3892/ijo.1.5.551.
Hemmer, J., Krause, H., Thein, T., Schon, E., & Kreidler, J. (1992). Comparison of flow cytometric DNA content in the primary tumor and in the corresponding lymph-node metastasis of patients with squamous cells carcinomas of the head and neck. International journal of oncology, 1(5), 551-3. https://doi.org/10.3892/ijo.1.5.551
Hemmer, J, et al. "Comparison of flow cytometric DNA content in the primary tumor and in the corresponding lymph-node metastasis of patients with squamous cells carcinomas of the head and neck." International journal of oncology vol. 1,5 (1992): 551-3. doi: https://doi.org/10.3892/ijo.1.5.551
Hemmer J, Krause H, Thein T, Schon E, Kreidler J. Comparison of flow cytometric DNA content in the primary tumor and in the corresponding lymph-node metastasis of patients with squamous cells carcinomas of the head and neck. Int J Oncol. 1992 Oct;1(5):551-3. doi: 10.3892/ijo.1.5.551. PMID: 21584579.
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Int J Oncol. 1992 Oct;1(5):551-3. doi: 10.3892/ijo.1.5.551.

Comparison of flow cytometric DNA content in the primary tumor and in the corresponding lymph-node metastasis of patients with squamous cells carcinomas of the head and neck.

International journal of oncology

J Hemmer, H Krause, T Thein, E Schon, J Kreidler

PMID: 21584579 DOI: 10.3892/ijo.1.5.551

Abstract

The clonal DNA content of the cell populations of primary tumors and corresponding lymph node metastases was analysed by DNA flow cytometry in 48 patients with squamous cell carcinoma of the oral cavity. Three primary tumors were diploid, two associated with diploid metastases, one showing an aneuploid cell line in the secondary lesion. Fourty-five cases were aneuploid in both the primary tumors and in the synchronous metastases, all characterized by nearly identical DNA indices of the corresponding primary and secondary lesions. With few exceptions, aneuploidy formation appears to take place prior to dissemination of metastatic cells.

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