Display options
Cite
Yates AJ, Conley J. Interactive effects of insulin, IGF-I and GMl ganglioside on growth of PC12 cells. Restor Neurol Neurosci. 1992;4(1):51-4doi: 10.3233/RNN-1992-4107.
Yates, A. J., & Conley, J. (1992). Interactive effects of insulin, IGF-I and GMl ganglioside on growth of PC12 cells. Restorative neurology and neuroscience, 4(1), 51-4. https://doi.org/10.3233/RNN-1992-4107
Yates, A J, and Conley, J. "Interactive effects of insulin, IGF-I and GMl ganglioside on growth of PC12 cells." Restorative neurology and neuroscience vol. 4,1 (1992): 51-4. doi: https://doi.org/10.3233/RNN-1992-4107
Yates AJ, Conley J. Interactive effects of insulin, IGF-I and GMl ganglioside on growth of PC12 cells. Restor Neurol Neurosci. 1992 Jan 01;4(1):51-4. doi: 10.3233/RNN-1992-4107. PMID: 21551654.
Copy Download .nbib Format: NLM
Share it on

Restor Neurol Neurosci. 1992 Jan 01;4(1):51-4. doi: 10.3233/RNN-1992-4107.

Interactive effects of insulin, IGF-I and GMl ganglioside on growth of PC12 cells.

Restorative neurology and neuroscience

A J Yates, J Conley

Affiliations

  1. Division of Neuropathology, Department of Pathology, The Ohio State University, Columbus, OH (USA).

PMID: 21551654 DOI: 10.3233/RNN-1992-4107

Abstract

PC12 cells grow in serum-free medium (SFM) if high doses of insulin (5-50 μg/ml), or combined insulin (5 μg/ml) and insulin-like growth factor-I (3 ng/ml) are added daily. Ganglioside GMl counteracts these effects in a dose-responsive fashion between 10 nM and 50 μM. This provides a serum-free system to study the interactive effects of gangliosides on growth and neuritogenesis in PC12 cells.

Publication Types