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Lewin-Kowalik J, Barski JJ, Krause M, et al. Neurotrophic effect of submicrosomal fractions obtained from pre-degenerated peripheral nerves. Restor Neurol Neurosci. 1994;7(2):71-8doi: 10.3233/RNN-1994-7202.
Lewin-Kowalik, J., Barski, J. J., Krause, M., Górka, D., Golka, B., & Larysz-Brysz, M. (1994). Neurotrophic effect of submicrosomal fractions obtained from pre-degenerated peripheral nerves. Restorative neurology and neuroscience, 7(2), 71-8. https://doi.org/10.3233/RNN-1994-7202
Lewin-Kowalik, J, et al. "Neurotrophic effect of submicrosomal fractions obtained from pre-degenerated peripheral nerves." Restorative neurology and neuroscience vol. 7,2 (1994): 71-8. doi: https://doi.org/10.3233/RNN-1994-7202
Lewin-Kowalik J, Barski JJ, Krause M, Górka D, Golka B, Larysz-Brysz M. Neurotrophic effect of submicrosomal fractions obtained from pre-degenerated peripheral nerves. Restor Neurol Neurosci. 1994 Jan 01;7(2):71-8. doi: 10.3233/RNN-1994-7202. PMID: 21551774.
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Restor Neurol Neurosci. 1994 Jan 01;7(2):71-8. doi: 10.3233/RNN-1994-7202.

Neurotrophic effect of submicrosomal fractions obtained from pre-degenerated peripheral nerves.

Restorative neurology and neuroscience

J Lewin-Kowalik, J J Barski, M Krause, D Górka, B Golka, M Larysz-Brysz

Affiliations

  1. Department of Physiology, Silesian Medical School, ul. Medyków 18, 40-762 Katowice, Poland.

PMID: 21551774 DOI: 10.3233/RNN-1994-7202

Abstract

Submicrosomal fractions obtained from pre-degenerated distal stumps of sciatic nerves were implanted by means of connective tissue chambers into the injured hippocampus for 8 and 18 weeks. The nerve stumps were allowed to pre-degenerate for 7, 28 and 35 days. The neuronal outgrowth was examined by means of FITC-HRP injected into the chamber. Eight weeks postoperatively the greatest number of traced cells was present in brains treated with the fraction obtained from nerves pre-degenerated for 7 days. Eighteen weeks following implantation the greatest number of FITC-HRP positive cells was found in brains grafted with the fraction from nerves pre-degenerated for 35 days.

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