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Beazley LD, Tennant M, Dunlop SA. The effect of a chronic breakdown of the blood-optic nerve barrier on the severed optic nerve in adult rat. Restor Neurol Neurosci. 1996;10(2):95-101doi: 10.3233/RNN-1996-10205.
Beazley, L. D., Tennant, M., & Dunlop, S. A. (1996). The effect of a chronic breakdown of the blood-optic nerve barrier on the severed optic nerve in adult rat. Restorative neurology and neuroscience, 10(2), 95-101. https://doi.org/10.3233/RNN-1996-10205
Beazley, L D, et al. "The effect of a chronic breakdown of the blood-optic nerve barrier on the severed optic nerve in adult rat." Restorative neurology and neuroscience vol. 10,2 (1996): 95-101. doi: https://doi.org/10.3233/RNN-1996-10205
Beazley LD, Tennant M, Dunlop SA. The effect of a chronic breakdown of the blood-optic nerve barrier on the severed optic nerve in adult rat. Restor Neurol Neurosci. 1996 Jan 01;10(2):95-101. doi: 10.3233/RNN-1996-10205. PMID: 21551858.
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Restor Neurol Neurosci. 1996 Jan 01;10(2):95-101. doi: 10.3233/RNN-1996-10205.

The effect of a chronic breakdown of the blood-optic nerve barrier on the severed optic nerve in adult rat.

Restorative neurology and neuroscience

L D Beazley, M Tennant, S A Dunlop

Affiliations

  1. Department of Zoology, The University of Western Australia, 6009 Nedlands, Australia.

PMID: 21551858 DOI: 10.3233/RNN-1996-10205

Abstract

The changes brought about in the severed optic nerve of an adult rat when the blood-optic nerve barrier was chronically broken down by the local application of a solution of mannitol is described. Axonal labelling indicated that axons did not regenerate across the lesion site, refuting the suggestion that breakdown of the blood-optic nerve barrier can stimulate axonal regeneration. However, we observed that blood vessels were dilated and, between the eye and lesion site, provided a substrate for regenerating axonal sprouts. We suggest that blood-borne agents may directly or indirectly influence the navigation of the growth cones of regrowing axons.

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