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Dias FM, Kummer A, Doyle FC, et al. Psychiatric disorders in primary focal dystonia and in Parkinson's disease. Neuropsychiatr Dis Treat. 2011;7:111-6doi: 10.2147/NDT.S17507.
Dias, F. M., Kummer, A., Doyle, F. C., Harsányi, E., Cardoso, F., Fontenelle, L. F., & Teixeira, A. L. (2011). Psychiatric disorders in primary focal dystonia and in Parkinson's disease. Neuropsychiatric disease and treatment, 7111-6. https://doi.org/10.2147/NDT.S17507
Dias, Fernando Mv, et al. "Psychiatric disorders in primary focal dystonia and in Parkinson's disease." Neuropsychiatric disease and treatment vol. 7 (2011): 111-6. doi: https://doi.org/10.2147/NDT.S17507
Dias FM, Kummer A, Doyle FC, Harsányi E, Cardoso F, Fontenelle LF, Teixeira AL. Psychiatric disorders in primary focal dystonia and in Parkinson's disease. Neuropsychiatr Dis Treat. 2011;7:111-6. doi: 10.2147/NDT.S17507. Epub 2011 Mar 14. PMID: 21552313; PMCID: PMC3083984.
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Neuropsychiatr Dis Treat. 2011;7:111-6. doi: 10.2147/NDT.S17507. Epub 2011 Mar 14.

Psychiatric disorders in primary focal dystonia and in Parkinson's disease.

Neuropsychiatric disease and treatment

Fernando Mv Dias, Arthur Kummer, Flávia Cp Doyle, Estefânia Harsányi, Francisco Cardoso, Leonardo F Fontenelle, Antônio Lúcio Teixeira

Affiliations

  1. Neuropsychiatric Branch.

PMID: 21552313 PMCID: PMC3083984 DOI: 10.2147/NDT.S17507

Abstract

BACKGROUND: Primary focal dystonia and Parkinson's disease are movement disorders that have contrasting motor phenotypes. The aim of this study was to compare the frequency and the severity of psychiatric disorders in primary focal dystonia and Parkinson's disease.

METHODS: Two groups of 30 patients matched by gender and age underwent a neurological and psychiatric assessment.

RESULTS: Parkinson's disease patients were diagnosed with higher rates of major depression (P = 0.02) and generalized anxiety disorder (P = 0.02), and greater severity of depressive symptoms (P = 0.04), while patients with primary focal dystonia exhibited increased severity of obsessive-compulsive symptoms (P = 0.02).

DISCUSSION: The difference in pathophysiology of primary focal dystonia and Parkinson's disease may explain the different psychiatric profiles of these two diseases. The increased frequency of affective symptoms in Parkinson's disease may be related to the fact that Parkinson's disease is a neurodegenerative disease marked by the loss of monoaminergic neurons which does not happen in primary focal dystonia.

CONCLUSION: The psychiatric profile differs in movement disorders with distinct neurobiological bases.

Keywords: Parkinson’s disease; depression; focal dystonia; neuropsychiatry; obsessive-compulsive disorder

References

  1. Mov Disord. 2008 Sep 15;23(12):1739-43 - PubMed
  2. Neurosci Lett. 2010 Jan 1;468(1):56-8 - PubMed
  3. J Drugs Dermatol. 2010 Jan;9(1):27-30 - PubMed
  4. Adv Neurol. 1976;14:1-5 - PubMed
  5. Neurobiol Aging. 2003 Mar-Apr;24(2):197-211 - PubMed
  6. Mov Disord. 2007 Apr 15;22(5):666-72 - PubMed
  7. Neurology. 2005 May 24;64(10):1799-801 - PubMed
  8. Arq Neuropsiquiatr. 2010 Aug;68(4):495-501 - PubMed
  9. Am J Med Genet C Semin Med Genet. 2009 May 15;151C(2):136-41 - PubMed
  10. J Nerv Ment Dis. 2003 Jul;191(7):465-73 - PubMed
  11. Cogn Behav Neurol. 2003 Dec;16(4):225-33 - PubMed
  12. J Neuropsychiatry Clin Neurosci. 2004 Winter;16(1):29-36 - PubMed
  13. J Neuroimmunol. 2009 Nov 30;216(1-2):122-5 - PubMed
  14. Behav Brain Res. 2008 Aug 22;191(2):148-52 - PubMed
  15. Psychiatry Res. 1992 Jun;42(3):267-72 - PubMed
  16. Parkinsonism Relat Disord. 2010 May;16(4):243-8 - PubMed
  17. Acta Psychiatr Scand Suppl. 2003;(417):19-27 - PubMed
  18. Arq Neuropsiquiatr. 2009 Sep;67(3B):930-9 - PubMed
  19. Acta Neuropsychiatr. 2010 Oct;22(5):223-7 - PubMed
  20. Braz J Psychiatry. 2006 Dec;28(4):265-9 - PubMed
  21. J Neurol Neurosurg Psychiatry. 2001 Oct;71(4):499-504 - PubMed
  22. Nat Rev Neurol. 2009 Nov;5(11):598-609 - PubMed
  23. Mov Disord. 2010 Mar 15;25(4):459-65 - PubMed
  24. Med Hypotheses. 2008;70(1):201-2 - PubMed
  25. Lancet Neurol. 2004 Nov;3(11):673-8 - PubMed
  26. Arq Neuropsiquiatr. 2005 Jun;63(2A):213-6 - PubMed
  27. Arch Ophthalmol. 2006 Jan;124(1):116-9 - PubMed
  28. Arq Neuropsiquiatr. 2009 Jun;67(2A):203-8 - PubMed
  29. Biol Psychiatry. 2002 Aug 15;52(4):356-61 - PubMed
  30. Neurology. 2007 Feb 13;68(7):522-4 - PubMed
  31. Gen Hosp Psychiatry. 2011 Sep-Oct;33(5):476-81 - PubMed
  32. Parkinsonism Relat Disord. 2005 Jun;11 Suppl 1:S39-40 - PubMed
  33. Lancet Neurol. 2002 Sep;1(5):316-25 - PubMed
  34. J Neurol Neurosurg Psychiatry. 2009 Oct;80(10):1176-9 - PubMed
  35. Brain. 2010 May;133(Pt 5):1552-64 - PubMed
  36. Acta Neurol Scand. 2004 Aug;110(2):118-23 - PubMed
  37. Arq Neuropsiquiatr. 2003 Sep;61(3B):777-81 - PubMed
  38. Prog Brain Res. 1990;85:119-46 - PubMed
  39. J Psychosom Res. 1998 Jun;44(6):687-90 - PubMed

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