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Hagel C, Schwartz P, Laas R, et al. Comparison of 4 proliferation markers and their significance for evaluation of tumor dignity in intracranial tumors. Int J Oncol. 1995;7(1):107-13doi: 10.3892/ijo.7.1.107.
Hagel, C., Schwartz, P., Laas, R., & Stavrou, D. (1995). Comparison of 4 proliferation markers and their significance for evaluation of tumor dignity in intracranial tumors. International journal of oncology, 7(1), 107-13. https://doi.org/10.3892/ijo.7.1.107
Hagel, C, et al. "Comparison of 4 proliferation markers and their significance for evaluation of tumor dignity in intracranial tumors." International journal of oncology vol. 7,1 (1995): 107-13. doi: https://doi.org/10.3892/ijo.7.1.107
Hagel C, Schwartz P, Laas R, Stavrou D. Comparison of 4 proliferation markers and their significance for evaluation of tumor dignity in intracranial tumors. Int J Oncol. 1995 Jul;7(1):107-13. doi: 10.3892/ijo.7.1.107. PMID: 21552814.
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Int J Oncol. 1995 Jul;7(1):107-13. doi: 10.3892/ijo.7.1.107.

Comparison of 4 proliferation markers and their significance for evaluation of tumor dignity in intracranial tumors.

International journal of oncology

C Hagel, P Schwartz, R Laas, D Stavrou

Affiliations

  1. UNIV HAMBURG,DEPT NEUROSURG,D-20246 HAMBURG,GERMANY.

PMID: 21552814 DOI: 10.3892/ijo.7.1.107

Abstract

The proliferation indices of immunohistochemically detected bromodeoxyuridine, Ki-67 antigen (antibodies Ki-67 and MIB 1), and proliferating cell nuclear antigen were determined manually and with computer assisted morphometry in 38 gliomas, 29 meningeomas, 9 metastases, and 16 other tumors. Comparing the markers among one another the highest correlation coefficient was found for bromodeoxyuridine and MIB 1 (0.9). The proliferation indices of all markers correlated significantly with the tumor grading. The highest correlation coefficient for proliferation index and grading (0.7) was calculated for the MIB 1 index determined in one high power field (0.0153 mm(2)) in the tissue area with the highest proliferative activity. Concerning applicability and correlation with tumor dignity MIB 1 was superior to the other three antibodies investigated.

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