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Abeysuriya V, Deen K, Dassanayake B, et al. Idiopathic pancreatitis is a consequence of an altering spectrum of bile nucleation time. BMC Res Notes. 2011;4:163doi: 10.1186/1756-0500-4-163.
Abeysuriya, V., Deen, K., Dassanayake, B., Kumarage, S., Navarathne, N., & Pathirana, A. (2011). Idiopathic pancreatitis is a consequence of an altering spectrum of bile nucleation time. BMC research notes, 4163. https://doi.org/10.1186/1756-0500-4-163
Abeysuriya, V, et al. "Idiopathic pancreatitis is a consequence of an altering spectrum of bile nucleation time." BMC research notes vol. 4 (2011): 163. doi: https://doi.org/10.1186/1756-0500-4-163
Abeysuriya V, Deen K, Dassanayake B, Kumarage S, Navarathne N, Pathirana A. Idiopathic pancreatitis is a consequence of an altering spectrum of bile nucleation time. BMC Res Notes. 2011 May 26;4:163. doi: 10.1186/1756-0500-4-163. PMID: 21615942; PMCID: PMC3123218.
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BMC Res Notes. 2011 May 26;4:163. doi: 10.1186/1756-0500-4-163.

Idiopathic pancreatitis is a consequence of an altering spectrum of bile nucleation time.

BMC research notes

V Abeysuriya, Ki Deen, Bk Dassanayake, Sk Kumarage, Nmm Navarathne, A Pathirana

Affiliations

  1. Department of Clinical Anatomy, Faculty of Medicine, Ragama, University of Kelaniya, Sri Lanka. [email protected].

PMID: 21615942 PMCID: PMC3123218 DOI: 10.1186/1756-0500-4-163

Abstract

BACKGROUND: The pathogenesis of idiopathic pancreatitis (IP) remains poorly understood. Our hypothesis is that IP is a sequel of micro-crystallization of hepatic bile.

METHODS: A prospective case control study compared 55 patients; symptomatic cholelithiasis - 30 (14 male, median age 36 years; mean BMI - 25.1 kg/m2), gallstone pancreatitis - 9 (3 male, median age 35 years; mean BMI - 24.86 kg/m2 ) and IP - 16 (9 male, median age 34 years; mean BMI -23.34 kg/m2) with 30 controls (15 male, median age 38 years; mean BMI = 24.5 kg/m2) undergoing laparotomy for conditions not related to the gall bladder and bile duct. Ultrafiltered bile from the common hepatic duct in patients and controls was incubated in anaerobic conditions and examined by polarized light microscopy to assess bile nucleation time (NT). In the analysis, the mean NT of patients with gallstones and gallstone pancreatitis was taken as a cumulative mean NT for those with established gallstone disease (EGD).

RESULTS: Patients were similar to controls. Mean NT in all groups of patients was significantly shorter than controls (EGD cumulative mean NT, 1.73 +/- 0.2 days vs. controls, 12.74 +/- 0.4 days, P = 0.001 and IP patients mean NT, 3.1 +/- 0.24 days vs. controls, 12.74 +/- 0.4 days, P = 0.001). However, NT in those with IP was longer compared with those with EGD (mean NT in IP, 3.1 +/- 0.24 days vs. cumulative mean in EGD: 1.73 +/- 0.2 days, P = 0.002).

CONCLUSION: Nucleation time of bile in patients with IP is abnormal and is intermediate to nucleation time of lithogenic bile at one end of the spectrum of lithogenicity and non-lithogenic bile, at the other end.

References

  1. Rev Med Chil. 1997 Aug;125(8):869-78 - PubMed
  2. N Engl J Med. 1993 Feb 11;328(6):412-21 - PubMed
  3. Gastrointest Endosc. 2002 Feb;55(2):163-6 - PubMed
  4. N Engl J Med. 2006 Dec 21;355(25):2670-6 - PubMed
  5. Curr Gastroenterol Rep. 2005 May;7(2):132-40 - PubMed
  6. Biochim Biophys Acta. 1992 Jan 16;1138(1):41-5 - PubMed
  7. Eur J Gastroenterol Hepatol. 2008 Oct;20(10):1020-3 - PubMed
  8. Br J Surg. 1988 May;75(5):450-3 - PubMed
  9. Arq Gastroenterol. 2000 Apr-Jun;37(2):93-101 - PubMed
  10. Gastroenterol Clin Biol. 1984 Mar;8(3):260-3 - PubMed
  11. Trop Gastroenterol. 2001 Oct-Dec;22(4):205-6 - PubMed
  12. Scand J Gastroenterol. 1988 Oct;23(8):948-54 - PubMed
  13. Gastroenterology. 1991 Dec;101(6):1701-9 - PubMed
  14. J Gastroenterol Hepatol. 2004 Oct;19(10):1206-11 - PubMed
  15. Gut. 1997 Aug;41(2):138-41 - PubMed
  16. N Engl J Med. 1992 Feb 27;326(9):589-93 - PubMed
  17. Gastroenterology. 1988 Nov;95(5):1339-43 - PubMed
  18. Rev Esp Enferm Dig. 1997 Nov;89(11):843-54 - PubMed
  19. Gastrointest Endosc. 2002 Feb;55(2):157-62 - PubMed
  20. Ceylon Med J. 2005 Mar;50(1):5-10 - PubMed

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