Display options
Cite
Daumke O, Gao S, von der Malsburg A, et al. Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module. Small GTPases. 2010;1(1):62-64doi: 10.4161/sgtp.1.1.12989.
Daumke, O., Gao, S., von der Malsburg, A., Haller, O., & Kochs, G. (2010). Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module. Small GTPases, 1(1), 62-64. https://doi.org/10.4161/sgtp.1.1.12989
Daumke, Oliver, et al. "Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module." Small GTPases vol. 1,1 (2010): 62-64. doi: https://doi.org/10.4161/sgtp.1.1.12989
Daumke O, Gao S, von der Malsburg A, Haller O, Kochs G. Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module. Small GTPases. 2010 Jul;1(1):62-64. doi: 10.4161/sgtp.1.1.12989. PMID: 21686120; PMCID: PMC3109478.
Copy Download .nbib Format: NLM
Share it on

Small GTPases. 2010 Jul;1(1):62-64. doi: 10.4161/sgtp.1.1.12989.

Structure of the MxA stalk elucidates the assembly of ring-like units of an antiviral module.

Small GTPases

Oliver Daumke, Song Gao, Alexander von der Malsburg, Otto Haller, Georg Kochs

Affiliations

  1. Max-Delbrück-Centrum for Molecular Medicine; Crystallography; Berlin, Germany.

PMID: 21686120 PMCID: PMC3109478 DOI: 10.4161/sgtp.1.1.12989

Abstract

The dynamin-like MxA GTP ase (Myxovirus resistance protein 1) mediates cellular resistance against a wide range of viruses. MxA is composed of an amino-terminal G domain, a middle domain and a carboxy-terminal GTPase effector domain. We recently determined the structure of the middle domain and GTPase effector domain of MxA constituting an elongated helical stalk, and elucidated the mechanism how the stalk mediates formation of ring-like MxA oligomers. Here, we shortly review our work and discuss the MxA rings as functional units of a cellular module orchestrating and executing the antiviral response.

References

  1. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2082-6 - PubMed
  2. J Virol. 2007 Jul;81(13):7011-21 - PubMed
  3. Virology. 2006 Jan 5;344(1):119-30 - PubMed
  4. Nature. 2006 Dec 7;444(7120):766-9 - PubMed
  5. Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47 - PubMed
  6. Methods Enzymol. 2005;404:632-43 - PubMed
  7. Structure. 2007 Oct;15(10):1190-202 - PubMed
  8. Trends Biochem Sci. 2006 Sep;31(9):497-508 - PubMed
  9. Biochim Biophys Acta. 2010 Apr;1803(4):507-19 - PubMed
  10. J Biol Chem. 2010 Sep 10;285(37):28419-24 - PubMed
  11. Nature. 2010 May 27;465(7297):502-6 - PubMed
  12. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3153-8 - PubMed
  13. J Biol Chem. 2002 Jun 14;277(24):21829-35 - PubMed
  14. EMBO J. 2000 Sep 1;19(17):4555-64 - PubMed
  15. Science. 2006 Jul 21;313(5785):360-3 - PubMed
  16. Traffic. 2004 Oct;5(10):772-84 - PubMed
  17. Nature. 2007 Oct 18;449(7164):923-7 - PubMed
  18. Nature. 2010 May 27;465(7297):435-40 - PubMed

Publication Types