Display options
Cite
Valko PO, Siccoli MM, Schiller A, et al. Non-convulsive status epilepticus causing focal neurological deficits in CADASIL. BMJ Case Rep. 2009;2009doi: 10.1136/bcr.08.2008.0713.
Valko, P. O., Siccoli, M. M., Schiller, A., Wieser, H. G., & Jung, H. H. (2009). Non-convulsive status epilepticus causing focal neurological deficits in CADASIL. BMJ case reports, 2009. https://doi.org/10.1136/bcr.08.2008.0713
Valko, Philipp O, et al. "Non-convulsive status epilepticus causing focal neurological deficits in CADASIL." BMJ case reports vol. 2009 (2009). doi: https://doi.org/10.1136/bcr.08.2008.0713
Valko PO, Siccoli MM, Schiller A, Wieser HG, Jung HH. Non-convulsive status epilepticus causing focal neurological deficits in CADASIL. BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.08.2008.0713. Epub 2009 Feb 02. PMID: 21686667; PMCID: PMC3029129.
Copy Download .nbib Format: NLM
Share it on

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.08.2008.0713. Epub 2009 Feb 02.

Non-convulsive status epilepticus causing focal neurological deficits in CADASIL.

BMJ case reports

Philipp O Valko, Massimiliano M Siccoli, Andreas Schiller, Heinz G Wieser, Hans H Jung

Affiliations

  1. Department of Neurology, University Hospital Zurich, Zurich, 8091, Switzerland.

PMID: 21686667 PMCID: PMC3029129 DOI: 10.1136/bcr.08.2008.0713

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary small vessel disease caused by mutations of the Notch3 gene. Clinical manifestations include migraine with or without aura, psychiatric disorders, recurrent ischaemic strokes and cognitive decline. Brain MRI shows confluent hyperintense signal alterations involving characteristically the anterior part of the temporal lobes and widespread areas of the deep and periventricular white matter. Focal or generalised seizures represent a rare neurological manifestation in CADASIL with a frequency of 6-10% in two large series. Status epilepticus, however, has not been reported so far. Herein we describe a patient with CADASIL with an acute focal neurological deficit following a prolonged migraine attack. The symptoms were first interpreted as an ischaemic stroke but subsequently diagnosed to be due to a non-convulsive status epilepticus.

References

  1. J Neurol Neurosurg Psychiatry. 2003 Feb;74(2):249-52 - PubMed
  2. Lancet. 1995 Oct 7;346(8980):934-9 - PubMed
  3. Neurogenetics. 2006 Jul;7(3):185-94 - PubMed
  4. Ann Neurol. 1998 Nov;44(5):731-9 - PubMed
  5. Neurology. 2000 Jan 25;54(2):350-4 - PubMed

Publication Types