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Meynaar IA, Droog W, Batstra M, et al. In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP. Crit Care Res Pract. 2011;2011:594645doi: 10.1155/2011/594645.
Meynaar, I. A., Droog, W., Batstra, M., Vreede, R., & Herbrink, P. (2011). In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP. Critical care research and practice, 2011594645. https://doi.org/10.1155/2011/594645
Meynaar, Iwan A, et al. "In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP." Critical care research and practice vol. 2011 (2011): 594645. doi: https://doi.org/10.1155/2011/594645
Meynaar IA, Droog W, Batstra M, Vreede R, Herbrink P. In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP. Crit Care Res Pract. 2011;2011:594645. doi: 10.1155/2011/594645. Epub 2011 May 15. PMID: 21687569; PMCID: PMC3113363.
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Crit Care Res Pract. 2011;2011:594645. doi: 10.1155/2011/594645. Epub 2011 May 15.

In Critically Ill Patients, Serum Procalcitonin Is More Useful in Differentiating between Sepsis and SIRS than CRP, Il-6, or LBP.

Critical care research and practice

Iwan A Meynaar, Wouter Droog, Manou Batstra, Rolf Vreede, Paul Herbrink

Affiliations

  1. Intensive Care Unit of the Reinier de Graaf Groep, Reinier de Graafweg 3-11, 2625AD Delft, The Netherlands.

PMID: 21687569 PMCID: PMC3113363 DOI: 10.1155/2011/594645

Abstract

We studied the usefulness of serum procalcitonin (PCT), interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP) levels and C-reactive protein (CRP) levels, in differentiating between systemic inflammatory response syndrome (SIRS) and sepsis in critically ill patients. Methods. In this single centre prospective observational study we included all consecutive patients admitted with SIRS or sepsis to the ICU. Blood samples for measuring CRP, PCT, IL-6 and LBP were taken every day until ICU discharge. Results. A total of 76 patients were included, 32 with sepsis and 44 with SIRS. Patients with sepsis were sicker on admission and had a higher mortality. CRP, PCT, IL-6 and LBP levels were significantly higher in patients with sepsis as compared to SIRS. With PCT levels in the first 24 hours after ICU admission <2 ng/mL, sepsis was virtually excluded (negative predictive value 97%). With PCT >10 ng/mL, sepsis with bacterial infection was very likely (positive predictive value 88%). PCT was best at discriminating between SIRS and sepsis with the highest area under the ROC curve (0.95, 95% CI 0.90-0.99). Discussion. This study showed that PCT is more useful than LBP, CRP and IL-6 in differentiating sepsis from SIRS.

References

  1. Intensive Care Med. 2000 Mar;26 Suppl 2:S148-52 - PubMed
  2. Crit Care Med. 2010 Nov;38(11):2229-41 - PubMed
  3. Crit Care. 2010;14(1):R15 - PubMed
  4. Am J Epidemiol. 2004 May 1;159(9):882-90 - PubMed
  5. Chest. 1992 Jun;101(6):1644-55 - PubMed
  6. Crit Care Clin. 2006 Jul;22(3):503-19, ix-x - PubMed
  7. J Clin Epidemiol. 2003 Nov;56(11):1129-35 - PubMed
  8. Lancet Infect Dis. 2007 Mar;7(3):210-7 - PubMed
  9. Crit Care Med. 2008 Jan;36(1):296-327 - PubMed
  10. Crit Care Med. 2000 Jan;28(1):104-9 - PubMed
  11. Crit Care Med. 2004 May;32(5):1166-9 - PubMed
  12. Crit Care Med. 2006 Jul;34(7):1996-2003 - PubMed
  13. Clin Chest Med. 2008 Dec;29(4):591-603, vii - PubMed
  14. J Infect Dis. 2003 Jan 15;187(2):287-91 - PubMed

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