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Arosio B, Mastronardi L, Gussago C, et al. Adenosine A(2A) Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment. Int J Alzheimers Dis. 2011;2011:484021doi: 10.4061/2011/484021.
Arosio, B., Mastronardi, L., Gussago, C., Nicolini, P., Casè, A., Ziglioli, E., & Bergamaschini, L. (2011). Adenosine A(2A) Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment. International journal of Alzheimer's disease, 2011484021. https://doi.org/10.4061/2011/484021
Arosio, Beatrice, et al. "Adenosine A(2A) Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment." International journal of Alzheimer's disease vol. 2011 (2011): 484021. doi: https://doi.org/10.4061/2011/484021
Arosio B, Mastronardi L, Gussago C, Nicolini P, Casè A, Ziglioli E, Bergamaschini L. Adenosine A(2A) Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment. Int J Alzheimers Dis. 2011;2011:484021. doi: 10.4061/2011/484021. Epub 2011 May 10. PMID: 21629668; PMCID: PMC3101508.
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Int J Alzheimers Dis. 2011;2011:484021. doi: 10.4061/2011/484021. Epub 2011 May 10.

Adenosine A(2A) Receptor and IL-10 in Peripheral Blood Mononuclear Cells of Patients with Mild Cognitive Impairment.

International journal of Alzheimer's disease

Beatrice Arosio, Luigina Mastronardi, Cristina Gussago, Paola Nicolini, Alessandra Casè, Eleonora Ziglioli, Luigi Bergamaschini

Affiliations

  1. Dipartimento di Medicina Interna, Università degli Studi di Milano & Unita di Geriatria, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Pace 9, 20122 Milano, Italy.

PMID: 21629668 PMCID: PMC3101508 DOI: 10.4061/2011/484021

Abstract

Adenosine suppresses immune responses through the A(2A) receptor (A(2A)R). This study investigated the interleukin 10 (IL-10) genetic profile and the expression of A(2A)R in peripheral blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer disease (AD), and age-matched controls to verify, if they may help distinguish different forms of cognitive decline. We analyzed the IL-10 genotype and the expression of A(2A)R in 41 subjects with AD, 10 with amnestic MCI (a-MCI), 49 with multiple cognitive domain MCI (mcd-MCI), and 46 controls. There was a significant linear increase in A(2A)R mRNA levels and A(2A)R density from mcd-MCI to a-MCI, with intermediate levels being found in AD. The IL-10 AA genotype frequency was 67% in a-MCI, 46% in AD, 35% in mcd-MCI, and 20% in controls. These data suggest that the assessment of the IL-10 genotype and the expression of A(2A)R in PBMCs may be a valuable means of differentiating between a-MCI and mcd-MCI.

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