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Kostenko S, Dumitriu G, Lægreid KJ, et al. Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase. World J Biol Chem. 2011;2(5):73-89doi: 10.4331/wjbc.v2.i5.73.
Kostenko, S., Dumitriu, G., Lægreid, K. J., & Moens, U. (2011). Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase. World journal of biological chemistry, 2(5), 73-89. https://doi.org/10.4331/wjbc.v2.i5.73
Kostenko, Sergiy, et al. "Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase." World journal of biological chemistry vol. 2,5 (2011): 73-89. doi: https://doi.org/10.4331/wjbc.v2.i5.73
Kostenko S, Dumitriu G, Lægreid KJ, Moens U. Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase. World J Biol Chem. 2011 May 26;2(5):73-89. doi: 10.4331/wjbc.v2.i5.73. PMID: 21666810; PMCID: PMC3110898.
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World J Biol Chem. 2011 May 26;2(5):73-89. doi: 10.4331/wjbc.v2.i5.73.

Physiological roles of mitogen-activated-protein-kinase-activated p38-regulated/activated protein kinase.

World journal of biological chemistry

Sergiy Kostenko, Gianina Dumitriu, Kari Jenssen Lægreid, Ugo Moens

Affiliations

  1. Sergiy Kostenko, Gianina Dumitriu, Kari Jenssen Lægreid, Ugo Moens, Faculty of Health Sciences, Institute of Medical Biology, University of Tromsø, NO-9037 Tromsø, Norway.

PMID: 21666810 PMCID: PMC3110898 DOI: 10.4331/wjbc.v2.i5.73

Abstract

Mitogen-activated protein kinases (MAPKs) are a family of proteins that constitute signaling pathways involved in processes that control gene expression, cell division, cell survival, apoptosis, metabolism, differentiation and motility. The MAPK pathways can be divided into conventional and atypical MAPK pathways. The first group converts a signal into a cellular response through a relay of three consecutive phosphorylation events exerted by MAPK kinase kinases, MAPK kinase, and MAPK. Atypical MAPK pathways are not organized into this three-tiered cascade. MAPK that belongs to both conventional and atypical MAPK pathways can phosphorylate both non-protein kinase substrates and other protein kinases. The latter are referred to as MAPK-activated protein kinases. This review focuses on one such MAPK-activated protein kinase, MAPK-activated protein kinase 5 (MK5) or p38-regulated/activated protein kinase (PRAK). This protein is highly conserved throughout the animal kingdom and seems to be the target of both conventional and atypical MAPK pathways. Recent findings on the regulation of the activity and subcellular localization, bona fide interaction partners and physiological roles of MK5/PRAK are discussed.

Keywords: Extracellular signal-regulated kinase; Mitogen-activated protein kinase; Phosphorylation; Protein interaction; Protein kinase A; Subcellular localization; p38-regulated/activated protein kinase

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