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Payne CM, Crowley-Skillicorn C, Bernstein C, et al. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clin Exp Gastroenterol. 2011;4:75-119doi: 10.2147/CEG.S17114.
Payne, C. M., Crowley-Skillicorn, C., Bernstein, C., Holubec, H., & Bernstein, H. (2011). Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clinical and experimental gastroenterology, 475-119. https://doi.org/10.2147/CEG.S17114
Payne, Claire M, et al. "Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis." Clinical and experimental gastroenterology vol. 4 (2011): 75-119. doi: https://doi.org/10.2147/CEG.S17114
Payne CM, Crowley-Skillicorn C, Bernstein C, Holubec H, Bernstein H. Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis. Clin Exp Gastroenterol. 2011;4:75-119. doi: 10.2147/CEG.S17114. Epub 2011 May 03. PMID: 21753893; PMCID: PMC3132853.
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Clin Exp Gastroenterol. 2011;4:75-119. doi: 10.2147/CEG.S17114. Epub 2011 May 03.

Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.

Clinical and experimental gastroenterology

Claire M Payne, Cheray Crowley-Skillicorn, Carol Bernstein, Hana Holubec, Harris Bernstein

Affiliations

  1. Department of Cell Biology and Anatomy, College of Medicine, University of Arizona Tucson, AZ, USA.

PMID: 21753893 PMCID: PMC3132853 DOI: 10.2147/CEG.S17114

Abstract

Chromosomal instability is a major pathway of sporadic colon carcinogenesis. Chromosome arm 1p appears to be one of the "hot spots" in the non-neoplastic mucosa that, when deleted, is associated with the initiation of carcinogenesis. Chromosome arm 1p contains genes associated with DNA repair, spindle checkpoint function, apoptosis, multiple microRNAs, the Wnt signaling pathway, tumor suppression, antioxidant activities, and defense against environmental toxins. Loss of 1p is dangerous since it would likely contribute to genomic instability leading to tumorigenesis. The 1p deletion-associated colon carcinogenesis pathways are reviewed at the molecular and cellular levels. Sporadic colon cancer is strongly linked to a high-fat/low-vegetable/low-micronutrient, Western-style diet. We also consider how selected dietary-related compounds (eg, excess hydrophobic bile acids, and low levels of folic acid, niacin, plant-derived antioxidants, and other modulatory compounds) might affect processes leading to chromosomal deletions, and to the molecular and cellular pathways specifically altered by chromosome 1p loss.

Keywords: cellular pathways; chromosome 1p; colon carcinogenesis; molecular pathways

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