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Turkmen K, Altintepe L, Guney I, et al. Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient. Int J Nephrol Renovasc Dis. 2010;3:65-8doi: 10.2147/ijnrd.s11077.
Turkmen, K., Altintepe, L., Guney, I., Aydogdu, I., Koc, O., Erkut, M. A., & Tonbul, H. Z. (2010). Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient. International journal of nephrology and renovascular disease, 365-8. https://doi.org/10.2147/ijnrd.s11077
Turkmen, Kultigin, et al. "Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient." International journal of nephrology and renovascular disease vol. 3 (2010): 65-8. doi: https://doi.org/10.2147/ijnrd.s11077
Turkmen K, Altintepe L, Guney I, Aydogdu I, Koc O, Erkut MA, Tonbul HZ. Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient. Int J Nephrol Renovasc Dis. 2010;3:65-8. doi: 10.2147/ijnrd.s11077. Epub 2010 Jun 04. PMID: 21694931; PMCID: PMC3108775.
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Int J Nephrol Renovasc Dis. 2010;3:65-8. doi: 10.2147/ijnrd.s11077. Epub 2010 Jun 04.

Uncontrolled hypertension secondary to leukemic cell infiltration of kidneys in a hemodialysis patient.

International journal of nephrology and renovascular disease

Kultigin Turkmen, Lutfullah Altintepe, Ibrahim Guney, Ismet Aydogdu, Osman Koc, Mehmet Ali Erkut, Halil Zeki Tonbul

Affiliations

  1. Department of Nephrology, Meram School of Medicine, Selcuk University.

PMID: 21694931 PMCID: PMC3108775 DOI: 10.2147/ijnrd.s11077

Abstract

Leukemic infiltration of the kidney is usually silent, and the admission of the patients with renal dysfunction or acute kidney injury is uncommon. We present a 34-year old hemodialysis patient with new onset of uncontrolled hypertension, erythropoietin-resistant anemia, thrombocytopenia, and Bell's palsy. On admission, his blood pressure (BP) was 210/110 mmHg and he had petechiae and purpura at upper and lower extremities. Renal ultrasonography (USG) showed bilaterally enlarged kidneys without hydronephrosis, unlike his previous USG, which determined bilaterally atrophic kidneys. Acute lymphoblastic leukemia, hypertensive crisis due to bilateral leukemic cell infiltration of kidneys, tumor lysis syndrome, and leukemic involvement of the facial nerve were diagnosed. Despite intense antihypertensive management, his BP was not controlled. After prednisolone, daunorubicine, and vincristine therapy, the size of kidneys diminished and his BP dropped under normal range. In conclusion, pathological findings such as uncontrolled hypertension, flank pain, skin rashes, and abnormal blood count should be considered carefully, even in patients with end-stage renal disease receiving renal replacement therapy.

2010 Turkmen et al, publisher and licensee Dove Medical Press Ltd.

Keywords: hemodialysis; leukemic cell infiltration; uncontrolled hypertension

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