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de Souza FR, Vozzi PA, Vila RA, et al. Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus). Genet Mol Biol. 2010;33(1):68-70doi: 10.1590/S1415-47572009005000098.
de Souza, F. R., Vozzi, P. A., Vila, R. A., Boligon, A. A., Galerani, M. A., Lobo, R. B., & Martelli, L. R. (2010). Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus). Genetics and molecular biology, 33(1), 68-70. https://doi.org/10.1590/S1415-47572009005000098
de Souza, Fabio Ricardo Pablos, et al. "Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus)." Genetics and molecular biology vol. 33,1 (2010): 68-70. doi: https://doi.org/10.1590/S1415-47572009005000098
de Souza FR, Vozzi PA, Vila RA, Boligon AA, Galerani MA, Lobo RB, Martelli LR. Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus). Genet Mol Biol. 2010 Jan;33(1):68-70. doi: 10.1590/S1415-47572009005000098. Epub 2010 Mar 01. PMID: 21637607; PMCID: PMC3036085.
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Genet Mol Biol. 2010 Jan;33(1):68-70. doi: 10.1590/S1415-47572009005000098. Epub 2010 Mar 01.

Association between MUC1 gene polymorphism and expected progeny differences in Nelore cattle (Bos primigenius indicus).

Genetics and molecular biology

Fabio Ricardo Pablos de Souza, Pedro Alejandro Vozzi, Reginaldo Aparecido Vila, Arione Augusti Boligon, Marli Aparecida Vani Galerani, Raysildo Barbosa Lobo, Lucia Regina Martelli

Affiliations

  1. Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP Brazil.

PMID: 21637607 PMCID: PMC3036085 DOI: 10.1590/S1415-47572009005000098

Abstract

MUC1 is a heavily glycosylated mammalian transmembrane protein expressed by mucosal secretory tissues for both protection against microbial infection and lubrication. An important characteristic of MUC1 is its variable number of tandem repeats (VNTR) containing several sites for O-glycosylation. VNTR length has been associated with many human diseases and with certain economically important traits in domestic ruminants. The aim of the present study was to correlate the length of MUC1 gene VNTR with expected progeny differences (EPDs) obtained for growth, fertility and carcass traits. Five alleles were identified, with alleles containing short VNTRs being more frequent than those with long, thereby demonstrating that Brazilian Nelore cattle are characterized by high frequencies in short MUC1 VNTRs. Statistical analyses revealed there to be no significant association between VNTR length and EPDs for weight at 120 days (W(120) ), scrotal circumference at 365 (SC (365) ) and 450 (SC (450) ) days, age at first calving (AFC), and rib eye area (REA).

Keywords: beef cattle; molecular marker; productive traits; quantitative trait locus

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