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Nobakht M, Gharavi MJ, Mousavizadeh K, et al. Alteration of rat hippocampal neurogenesis and neuronal nitric oxide synthase expression upon prenatal exposure to tamoxifen. Pathophysiology. 2011;18(4):263-72doi: 10.1016/j.pathophys.2011.01.002.
Nobakht, M., Gharavi, M. J., Mousavizadeh, K., Bakhshayesh, M., & Ghafourifar, P. (2011). Alteration of rat hippocampal neurogenesis and neuronal nitric oxide synthase expression upon prenatal exposure to tamoxifen. Pathophysiology : the official journal of the International Society for Pathophysiology, 18(4), 263-72. https://doi.org/10.1016/j.pathophys.2011.01.002
Nobakht, Maliheh, et al. "Alteration of rat hippocampal neurogenesis and neuronal nitric oxide synthase expression upon prenatal exposure to tamoxifen." Pathophysiology : the official journal of the International Society for Pathophysiology vol. 18,4 (2011): 263-72. doi: https://doi.org/10.1016/j.pathophys.2011.01.002
Nobakht M, Gharavi MJ, Mousavizadeh K, Bakhshayesh M, Ghafourifar P. Alteration of rat hippocampal neurogenesis and neuronal nitric oxide synthase expression upon prenatal exposure to tamoxifen. Pathophysiology. 2011 Sep;18(4):263-72. doi: 10.1016/j.pathophys.2011.01.002. Epub 2011 Jul 14. PMID: 21757325.
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Pathophysiology. 2011 Sep;18(4):263-72. doi: 10.1016/j.pathophys.2011.01.002. Epub 2011 Jul 14.

Alteration of rat hippocampal neurogenesis and neuronal nitric oxide synthase expression upon prenatal exposure to tamoxifen.

Pathophysiology : the official journal of the International Society for Pathophysiology

Maliheh Nobakht, Mohammad Javad Gharavi, Kazem Mousavizadeh, Maasoumeh Bakhshayesh, Pedram Ghafourifar

Affiliations

  1. Department of Histology and Neuroscience, School of Medicine, Tehran University of Medical Science, Tehran, Iran; Cellular and Molecular Research Center, Tehran University of Medical Science, Tehran, Iran; Anti-microbial Resistance Research Center, Tehran University of Medical Science, Tehran, Iran.

PMID: 21757325 DOI: 10.1016/j.pathophys.2011.01.002

Abstract

The present study delineates the effect of tamoxifen on neuronal density and expression of neuronal nitric oxide synthase (nNOS) in hippocampal nerve cells during prenatal and postnatal periods in rats. Pregnant rats were administered with tamoxifen one day prior to labor (E21) and on the childbirth day (E22). Hippocampi of embryos at E22 and newborns at postnatal days of 1, 7, and 21 (P1, P7, and P21) were investigated. Density of the neurons in areas of the developing hippocampus including cornu ammonis (CA1, CA3), dentate gyrus, and subiculum were studied. Our findings show that the number of pyramidal neurons was significantly decreased in CA1 and subiculum of tamoxifen-treated rats in E22, P1, and P7. We found that cellular density was lower in early stages of development, however, cellular density and thickness gradually increased during the development particularly in the third week. We found that nNOS expression was decreased in E22, P1, and P7 in animals treated with tamoxifen. The present study shows that tamoxifen affects development and differentiation of postnatal rat hippocampus, CA1 neurons, and nNOS expression.

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