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Ozsoy Y, Ozsoy M, Coskun T, et al. The effects of L-arginine on liver damage in experimental acute cholestasis an immunohistochemical study. HPB Surg. 2011;2011:306069doi: 10.1155/2011/306069.
Ozsoy, Y., Ozsoy, M., Coskun, T., Yavuz, K., Ozbilgin, K., Namlı, K., Var, A., & Ozyurt, B. (2011). The effects of L-arginine on liver damage in experimental acute cholestasis an immunohistochemical study. HPB surgery : a world journal of hepatic, pancreatic and biliary surgery, 2011306069. https://doi.org/10.1155/2011/306069
Ozsoy, Yucel, et al. "The effects of L-arginine on liver damage in experimental acute cholestasis an immunohistochemical study." HPB surgery : a world journal of hepatic, pancreatic and biliary surgery vol. 2011 (2011): 306069. doi: https://doi.org/10.1155/2011/306069
Ozsoy Y, Ozsoy M, Coskun T, Yavuz K, Ozbilgin K, Namlı K, Var A, Ozyurt B. The effects of L-arginine on liver damage in experimental acute cholestasis an immunohistochemical study. HPB Surg. 2011;2011:306069. doi: 10.1155/2011/306069. Epub 2011 Jun 01. PMID: 21760660; PMCID: PMC3132489.
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HPB Surg. 2011;2011:306069. doi: 10.1155/2011/306069. Epub 2011 Jun 01.

The effects of L-arginine on liver damage in experimental acute cholestasis an immunohistochemical study.

HPB surgery : a world journal of hepatic, pancreatic and biliary surgery

Yucel Ozsoy, Mustafa Ozsoy, Teoman Coskun, Kaya Yavuz, Kemal Ozbilgin, Kemal Namlı, Ahmet Var, Beyhan Ozyurt

Affiliations

  1. Department of General Surgery, Manisa State Hospital, Manisa, 35630 ?zmir, Turkey.

PMID: 21760660 PMCID: PMC3132489 DOI: 10.1155/2011/306069

Abstract

Obstructive jaundice damages critical functions in the liver. Nitric oxide modulation would influence liver damage induced by biliary obstruction, and little is known about it Acute cholestasis was induced by bile duct ligation (BDL) in two groups of male Sprague-Dawley rats. L-Arginine or serum physiologic was administered to treatment and control group. Histopathological and immunohistochemical iNOS expression was investigated in hepatic tissue. Plasma enzyme activities were increased in acute cholestasis, and that L-arginine treatment partially but significantly prevented the elevation of these markers of liver damage (P <  .05). Also histopathology scoring showed that the liver injury was prevented and immunohistochemical iNOS activity was increased significantly in L-arginine group (P <  .05). This study shows that, after 7 days of biliary obstruction, liver damage is well established and exogenous L-arginine treatment partially but significantly prevented the liver injury in acute cholestasis.

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