Int J Cell Biol. 2011;2011:403623. doi: 10.1155/2011/403623. Epub 2011 Jun 21.

Tuberculosis: new aspects of an old disease.

International journal of cell biology

Luisa Jordao, Otilia V Vieira

PMID: 21760796 PMCID: PMC3132536 DOI: 10.1155/2011/403623

Abstract

Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycobacterium tuberculosis interference with phagosome maturation, less consensual mechanism like nitric oxide production, and new mechanisms, such as mycobacteria translocation to the cytosol, autophagy, and apoptosis/necrosis proposed mainly during the last decade.

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