Display options
Cite
Balachandran K, Sucosky P, Yoganathan AP. Hemodynamics and mechanobiology of aortic valve inflammation and calcification. Int J Inflam. 2011;2011:263870doi: 10.4061/2011/263870.
Balachandran, K., Sucosky, P., & Yoganathan, A. P. (2011). Hemodynamics and mechanobiology of aortic valve inflammation and calcification. International journal of inflammation, 2011263870. https://doi.org/10.4061/2011/263870
Balachandran, Kartik, et al. "Hemodynamics and mechanobiology of aortic valve inflammation and calcification." International journal of inflammation vol. 2011 (2011): 263870. doi: https://doi.org/10.4061/2011/263870
Balachandran K, Sucosky P, Yoganathan AP. Hemodynamics and mechanobiology of aortic valve inflammation and calcification. Int J Inflam. 2011;2011:263870. doi: 10.4061/2011/263870. Epub 2011 Jul 06. PMID: 21760982; PMCID: PMC3133012.
Copy Download .nbib Format: NLM
Share it on

Int J Inflam. 2011;2011:263870. doi: 10.4061/2011/263870. Epub 2011 Jul 06.

Hemodynamics and mechanobiology of aortic valve inflammation and calcification.

International journal of inflammation

Kartik Balachandran, Philippe Sucosky, Ajit P Yoganathan

Affiliations

  1. Wyss Institute for Biologically Inspired Engineering, School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

PMID: 21760982 PMCID: PMC3133012 DOI: 10.4061/2011/263870

Abstract

Cardiac valves function in a mechanically complex environment, opening and closing close to a billion times during the average human lifetime, experiencing transvalvular pressures and pulsatile and oscillatory shear stresses, as well as bending and axial stress. Although valves were originally thought to be passive pieces of tissue, recent evidence points to an intimate interplay between the hemodynamic environment and biological response of the valve. Several decades of study have been devoted to understanding these varied mechanical stimuli and how they might induce valve pathology. Here, we review efforts taken in understanding the valvular response to its mechanical milieu and key insights gained from in vitro and ex vivo whole-tissue studies in the mechanobiology of aortic valve remodeling, inflammation, and calcification.

References

  1. Circulation. 2007 Jan 23;115(3):377-86 - PubMed
  2. J Hypertens. 2005 Apr;23(4):867-73 - PubMed
  3. Cardiovasc Res. 1981 Apr;15(4):181-9 - PubMed
  4. Cardiovasc Pathol. 2007 Sep-Oct;16(5):268-76 - PubMed
  5. Circulation. 2004 Mar 2;109(8):942-50 - PubMed
  6. Biomech Model Mechanobiol. 2010 Feb;9(1):117-25 - PubMed
  7. J Thorac Cardiovasc Surg. 1987 Sep;94(3):367-74 - PubMed
  8. J Thorac Cardiovasc Surg. 1979 Jun;77(6):863-70 - PubMed
  9. Am J Pathol. 2010 Jul;177(1):49-57 - PubMed
  10. J Heart Valve Dis. 2008 Jan;17(1):62-73 - PubMed
  11. Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):936-42 - PubMed
  12. Circ Res. 2005 Apr 15;96(7):792-9 - PubMed
  13. Int J Biochem Cell Biol. 2003 Feb;35(2):113-8 - PubMed
  14. Tissue Eng. 2006 Apr;12(4):905-15 - PubMed
  15. Nat Clin Pract Cardiovasc Med. 2007 Feb;4(2):60-1 - PubMed
  16. J Biomech Eng. 2008 Jun;130(3):035001 - PubMed
  17. J Pathol. 2003 Jul;200(4):423-8 - PubMed
  18. Eur Heart J. 2005 Jul;26(13):1333-41 - PubMed
  19. J Heart Valve Dis. 2010 Jan;19(1):86-95; discussion 96 - PubMed
  20. Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1429-34 - PubMed
  21. Ann Biomed Eng. 2008 May;36(5):700-12 - PubMed
  22. J Heart Valve Dis. 2009 Jul;18(4):429-38 - PubMed
  23. Curr Vasc Pharmacol. 2005 Oct;3(4):353-7 - PubMed
  24. Circulation. 2009 Jul 28;120(4):334-42 - PubMed
  25. Philos Trans R Soc Lond B Biol Sci. 2007 Aug 29;362(1484):1489-503 - PubMed
  26. Circulation. 2006 Jun 20;113(24):2818-25 - PubMed
  27. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H395-405 - PubMed
  28. Circulation. 1993 Nov;88(5 Pt 1):2235-47 - PubMed
  29. Ann Biomed Eng. 2004 Apr;32(4):555-62 - PubMed
  30. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H756-64 - PubMed
  31. N Engl J Med. 2001 Sep 6;345(10):740-6 - PubMed
  32. Biomaterials. 2011 Apr;32(11):2885-93 - PubMed
  33. J Am Coll Cardiol. 1997 Mar 1;29(3):630-4 - PubMed
  34. Cardiovasc Pathol. 2002 Mar-Apr;11(2):69-77 - PubMed
  35. Ann Biomed Eng. 2006 Nov;34(11):1655-65 - PubMed
  36. Eur Heart J. 1988 Apr;9 Suppl E:13-7 - PubMed
  37. Curr Vasc Pharmacol. 2009 Jan;7(1):40-6 - PubMed
  38. Biomech Model Mechanobiol. 2012 Jan;11(1-2):171-82 - PubMed
  39. Ann Thorac Surg. 1986 Oct;42(4):434-40 - PubMed
  40. Lab Chip. 2010 Jan 21;10(2):227-34 - PubMed
  41. Ann Biomed Eng. 2011 Jun;39(6):1654-67 - PubMed
  42. J Biol Chem. 2003 Aug 15;278(33):31128-35 - PubMed
  43. Am Heart J. 1980 Feb;99(2):217-24 - PubMed
  44. In Vitro Cell Dev Biol. 1993 Jan;29A(1):41-50 - PubMed
  45. Circulation. 2001 Mar 20;103(11):1522-8 - PubMed
  46. Arteriosclerosis. 1986 Mar-Apr;6(2):220-9 - PubMed
  47. ASAIO J. 1997 May-Jun;43(3):181-6 - PubMed
  48. Cardiovasc Res. 2006 Aug 1;71(3):548-56 - PubMed
  49. Ann Biomed Eng. 2010 Nov;38(11):3280-94 - PubMed
  50. Ann Thorac Surg. 1995 Aug;60(2 Suppl):S156-8; discussion S159 - PubMed
  51. J Heart Valve Dis. 2006 Jan;15(1):34-41; discussion 42 - PubMed
  52. Ann Biomed Eng. 2001 Sep;29(9):752-63 - PubMed
  53. Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H224-31 - PubMed
  54. In Vitro Cell Dev Biol. 1986 Sep;22(9):500-7 - PubMed
  55. Ann N Y Acad Sci. 1995 Mar 27;752:286-99 - PubMed
  56. J Heart Valve Dis. 2000 Mar;9(2):250-4; discussion 254-5 - PubMed
  57. Circulation. 2001 Nov 20;104(21):2525-32 - PubMed
  58. Ann Biomed Eng. 2005 Sep;33(9):1158-66 - PubMed
  59. J Biomech. 1990;23(3):201-14 - PubMed
  60. Lab Invest. 1994 Jul;71(1):127-33 - PubMed
  61. Am J Pathol. 2007 Nov;171(5):1407-18 - PubMed
  62. Circulation. 1994 Aug;90(2):844-53 - PubMed
  63. Circulation. 2008 Aug 19;118(8):845-52 - PubMed
  64. Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):254-60 - PubMed
  65. Ann N Y Acad Sci. 2008 Mar;1123:30-40 - PubMed
  66. J Clin Invest. 1998 Aug 1;102(3):576-83 - PubMed
  67. J Clin Invest. 2003 Mar;111(6):897-906 - PubMed
  68. Circ Res. 1995 Nov;77(5):863-8 - PubMed
  69. J Am Coll Cardiol. 2001 Sep;38(3):827-34 - PubMed
  70. J Biomech Eng. 2005 Oct;127(5):857-61 - PubMed
  71. Med Biol Eng Comput. 1998 Jul;36(4):520-7 - PubMed
  72. Ann Biomed Eng. 1999 Jul-Aug;27(4):572-9 - PubMed
  73. J Biomech. 2011 May 17;44(8):1459-65 - PubMed
  74. Ann Biomed Eng. 2004 Nov;32(11):1461-70 - PubMed
  75. Science. 1983 Feb 18;219(4586):867-9 - PubMed
  76. J Am Coll Cardiol. 2009 Apr 21;53(16):1448-55 - PubMed
  77. J Heart Valve Dis. 2010 Sep;19(5):626-35 - PubMed
  78. Ann Thorac Surg. 2007 Mar;83(3):946-53 - PubMed
  79. N Engl J Med. 2008 Sep 25;359(13):1395-8 - PubMed
  80. Biomech Model Mechanobiol. 2012 Jan;11(1-2):231-44 - PubMed
  81. Proc Inst Mech Eng H. 1995;209(4):243-53 - PubMed
  82. Biomaterials. 2006 Apr;27(10):2233-46 - PubMed
  83. Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1721-8 - PubMed
  84. Circulation. 2003 May 6;107(17):2181-4 - PubMed
  85. Ann Thorac Surg. 1995 Aug;60(2 Suppl):S374-8 - PubMed
  86. Heart. 1997 Nov;78(5):472-4 - PubMed
  87. Circulation. 2007 Apr 17;115(15):2065-75 - PubMed
  88. Ann Thorac Surg. 2003 Feb;75(2):457-65; discussion 465-6 - PubMed
  89. J Heart Valve Dis. 2001 Nov;10(6):822-5; discussion 825-6 - PubMed
  90. J Heart Valve Dis. 2006 Sep;15(5):622-9 - PubMed

Publication Types