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Streiner DL, Norman GR. Correction for multiple testing: is there a resolution?. Chest. 2011;140(1):16-18doi: 10.1378/chest.11-0523.
Streiner, D. L., & Norman, G. R. (2011). Correction for multiple testing: is there a resolution?. Chest, 140(1), 16-18. https://doi.org/10.1378/chest.11-0523
Streiner, David L, and Norman, Geoffrey R. "Correction for multiple testing: is there a resolution?." Chest vol. 140,1 (2011): 16-18. doi: https://doi.org/10.1378/chest.11-0523
Streiner DL, Norman GR. Correction for multiple testing: is there a resolution?. Chest. 2011 Jul;140(1):16-18. doi: 10.1378/chest.11-0523. PMID: 21729890.
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Chest. 2011 Jul;140(1):16-18. doi: 10.1378/chest.11-0523.

Correction for multiple testing: is there a resolution?.

Chest

David L Streiner, Geoffrey R Norman

Affiliations

  1. Department of Psychiatry and Behavioural Neurosciences, Hamilton, ON, Canada; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address: [email protected].
  2. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada.

PMID: 21729890 DOI: 10.1378/chest.11-0523

Abstract

In most studies, many statistical tests are performed. They can be run to compare the groups at baseline, look at relationships among the various measures, and, for intervention trials, examine more than one end point. As the number of tests increases, so does the probability of finding at least one of them to be statistically significant just by chance (the problem of multiplicity). A number of procedures have been developed to deal with multiplicity, such as the Bonferroni correction, but there is continuing controversy regarding if and when these procedures should be used. In this article, we offer recommendations about when they should and should not be brought into play.

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