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J Indian Soc Periodontol. 2010 Oct;14(4):282-6. doi: 10.4103/0972-124X.76927.

Relevance of gingival crevice fluid components in assessment of periodontal disease - A critical analysis.

Journal of Indian Society of Periodontology

Sheetal Oswal, C D Dwarakanath

Affiliations

  1. Department of Periodontics and Implantology, Hasanamba Dental College and Hospital, Hassan, India.

PMID: 21731259 PMCID: PMC3118084 DOI: 10.4103/0972-124X.76927

Abstract

Monitoring infections which are episodic, site specific, localized or generalized, initiated by a number of microorganisms and assessed with measurement devices that have inherent shortcomings presents a difficult task. The lack of precise clinical criteria for assessment of periodontal disease has led to a search for alternative means of determining active disease sites, predicting future sites of breakdown and evaluating response to therapy. This paper highlights the potential array of biomarkers present in gingival crevice fluid (GCF) and provides an insight of which of these factors has the greatest diagnostic potential. The rationale behind using GCF as sampling source is also described. Finally it discusses the possible use of predictive chair side diagnostic tests in periodontitis.

Keywords: Biomarkers; GCF; diagnosis; periodontal disease

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