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Cadet JL, Brannock C, Ladenheim B, et al. Methamphetamine preconditioning causes differential changes in striatal transcriptional responses to large doses of the drug. Dose Response. 2010;9(2):165-81doi: 10.2203/dose-response.10-011.Cadet.
Cadet, J. L., Brannock, C., Ladenheim, B., McCoy, M. T., Beauvais, G., Hodges, A. B., Lehrmann, E., Wood, W. H., Becker, K. G., & Krasnova, I. N. (2011). Methamphetamine preconditioning causes differential changes in striatal transcriptional responses to large doses of the drug. Dose-response : a publication of International Hormesis Society, 9(2), 165-81. https://doi.org/10.2203/dose-response.10-011.Cadet
Cadet, Jean Lud, et al. "Methamphetamine preconditioning causes differential changes in striatal transcriptional responses to large doses of the drug." Dose-response : a publication of International Hormesis Society vol. 9,2 (2011): 165-81. doi: https://doi.org/10.2203/dose-response.10-011.Cadet
Cadet JL, Brannock C, Ladenheim B, McCoy MT, Beauvais G, Hodges AB, Lehrmann E, Wood WH, Becker KG, Krasnova IN. Methamphetamine preconditioning causes differential changes in striatal transcriptional responses to large doses of the drug. Dose Response. 2011;9(2):165-81. doi: 10.2203/dose-response.10-011.Cadet. Epub 2010 Jul 02. PMID: 21731535; PMCID: PMC3118766.
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Dose Response. 2011;9(2):165-81. doi: 10.2203/dose-response.10-011.Cadet. Epub 2010 Jul 02.

Methamphetamine preconditioning causes differential changes in striatal transcriptional responses to large doses of the drug.

Dose-response : a publication of International Hormesis Society

Jean Lud Cadet, Christie Brannock, Bruce Ladenheim, Michael T McCoy, Genevieve Beauvais, Amber B Hodges, Elin Lehrmann, William H Wood, Kevin G Becker, Irina N Krasnova

Affiliations

  1. Molecular Neuropsychiatry Research Branch, Intramural Research Program, NIDA/NIH/DHHS, Baltimore, MD, USA.

PMID: 21731535 PMCID: PMC3118766 DOI: 10.2203/dose-response.10-011.Cadet

Abstract

Methamphetamine (METH) is a toxic drug of abuse, which can cause significant decreases in the levels of monoamines in various brain regions. However, animals treated with progressively increasing doses of METH over several weeks are protected against the toxic effects of the drug. In the present study, we tested the possibility that this pattern of METH injections might be associated with transcriptional changes in the rat striatum, an area of the brain which is known to be very sensitive to METH toxicity and which is protected by METH preconditioning. We found that the presence and absence of preconditioning followed by injection of large doses of METH caused differential expression in different sets of striatal genes. Quantitative PCR confirmed METH-induced changes in some genes of interest. These include small heat shock 27 kD proteins 1 and 2 (HspB1 and HspB2), brain derived neurotrophic factor (BDNF), and heme oxygenase-1 (Hmox-1). Our observations are consistent with previous studies which have reported that ischemic or pharmacological preconditioning can cause reprogramming of gene expression after lethal ischemic insults. These studies add to the growing literature on the effects of preconditioning on the brain transcriptome.

Keywords: BDNF; heat shock proteins; methamphetamine; preconditioning; striatum

References

  1. J Neurosci. 1999 Nov 15;19(22):10107-15 - PubMed
  2. Adv Exp Med Biol. 2007;594:14-26 - PubMed
  3. Synapse. 2001 Jul;41(1):40-8 - PubMed
  4. Curr Opin Drug Discov Devel. 2006 Sep;9(5):580-6 - PubMed
  5. FASEB J. 2001 Aug;15(10):1745-52 - PubMed
  6. JAMA. 1967 Jul 31;201(5):305-9 - PubMed
  7. J Biol Chem. 2007 Aug 24;282(34):25088-99 - PubMed
  8. J Neurosci. 2008 May 28;28(22):5756-61 - PubMed
  9. Physiol Rev. 2008 Jan;88(1):211-47 - PubMed
  10. Stroke. 2007 Feb;38(2 Suppl):680-5 - PubMed
  11. Eur J Pharmacol. 2007 Mar 15;559(1):46-54 - PubMed
  12. PLoS One. 2009 Nov 12;4(11):e7812 - PubMed
  13. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):315-26 - PubMed
  14. Am J Psychiatry. 2003 Sep;160(9):1699-701 - PubMed
  15. Am J Addict. 2004 Mar-Apr;13(2):181-90 - PubMed
  16. J Biosci. 2007 Apr;32(3):595-610 - PubMed
  17. Addiction. 2007 Apr;102 Suppl 1:16-32 - PubMed
  18. Drug Alcohol Rev. 2008 May;27(3):253-62 - PubMed
  19. Genes Brain Behav. 2008 Mar;7(2):193-202 - PubMed
  20. Annu Rev Pharmacol Toxicol. 2010;50:323-54 - PubMed
  21. Lancet. 2003 Sep 27;362(9389):1028-37 - PubMed
  22. Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H847-55 - PubMed
  23. Brain Res Mol Brain Res. 2005 Oct 31;140(1-2):1-9 - PubMed
  24. J Addict Dis. 2002;21(1):61-74 - PubMed
  25. Neurotox Res. 2007 Apr;11(3-4):183-202 - PubMed
  26. FASEB J. 1999 Nov;13(14):2061-70 - PubMed
  27. J Neurochem. 2004 Jan;88(2):380-93 - PubMed
  28. Antioxid Redox Signal. 2007 Dec;9(12):2227-39 - PubMed
  29. PLoS One. 2009 Jun 30;4(6):e6092 - PubMed
  30. Int J Neuropsychopharmacol. 2008 Dec;11(8):1123-34 - PubMed
  31. J Neurochem. 1994 Jan;62(1):380-3 - PubMed
  32. Synapse. 1997 Feb;25(2):176-84 - PubMed
  33. Brain Res Mol Brain Res. 2005 Mar 24;134(1):147-54 - PubMed
  34. Mol Biol Cell. 2007 Sep;18(9):3681-91 - PubMed
  35. Am J Psychiatry. 2001 Mar;158(3):377-82 - PubMed
  36. Neuropsychol Rev. 2007 Sep;17(3):275-97 - PubMed
  37. J Neurochem. 2004 Apr;89(1):73-89 - PubMed
  38. PLoS One. 2010 Jan 20;5(1):e8790 - PubMed
  39. Dev Dyn. 2008 Jan;237(1):18-27 - PubMed
  40. Mol Pharmacol. 2000 Dec;58(6):1247-56 - PubMed
  41. J Psychol. 1998 Mar;132(2):227-37 - PubMed
  42. Arch Pharm Res. 2009 Aug;32(8):1163-76 - PubMed
  43. Arch Gen Psychiatry. 2006 Jan;63(1):90-100 - PubMed
  44. Mol Neurobiol. 2009 Feb;39(1):50-61 - PubMed
  45. Anesthesiology. 2007 Mar;106(3):538-47 - PubMed
  46. Eur J Pharmacol. 2003 Dec 15;482(1-3):151-4 - PubMed
  47. Results Probl Cell Differ. 2008;44:49-67 - PubMed
  48. Antioxid Redox Signal. 2004 Oct;6(5):895-913 - PubMed
  49. Neurotox Res. 2007 Feb;11(2):107-30 - PubMed
  50. Neurotox Res. 2009 Apr;15(3):252-9 - PubMed
  51. J Neurochem. 2005 Feb;92(4):790-7 - PubMed
  52. Ann N Y Acad Sci. 2006 Aug;1074:272-81 - PubMed
  53. Trends Neurosci. 2003 May;26(5):248-54 - PubMed
  54. Ageing Res Rev. 2008 Jan;7(1):8-20 - PubMed
  55. Nat Rev Neurosci. 2005 Jan;6(1):11-22 - PubMed
  56. Brain Res Rev. 2009 May;60(2):379-407 - PubMed
  57. Int J Hyperthermia. 2005 Aug;21(5):379-92 - PubMed
  58. FASEB J. 2003 Oct;17(13):1775-88 - PubMed
  59. J Neurochem. 2008 Jun;105(5):1873-85 - PubMed
  60. J Neurosci Res. 2008 Aug 1;86(10):2125-33 - PubMed

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