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Alshawsh MA, Abdulla MA, Ismail S, et al. Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. Evid Based Complement Alternat Med. 2011;2011:103039doi: 10.1155/2011/103039.
Alshawsh, M. A., Abdulla, M. A., Ismail, S., & Amin, Z. A. (2011). Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. Evidence-based complementary and alternative medicine : eCAM, 2011103039. https://doi.org/10.1155/2011/103039
Alshawsh, Mohammed A, et al. "Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats." Evidence-based complementary and alternative medicine : eCAM vol. 2011 (2011): 103039. doi: https://doi.org/10.1155/2011/103039
Alshawsh MA, Abdulla MA, Ismail S, Amin ZA. Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats. Evid Based Complement Alternat Med. 2011;2011:103039. doi: 10.1155/2011/103039. Epub 2011 May 05. PMID: 21647311; PMCID: PMC3106356.
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Evid Based Complement Alternat Med. 2011;2011:103039. doi: 10.1155/2011/103039. Epub 2011 May 05.

Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats.

Evidence-based complementary and alternative medicine : eCAM

Mohammed A Alshawsh, Mahmood Ameen Abdulla, Salmah Ismail, Zahra A Amin

Affiliations

  1. Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

PMID: 21647311 PMCID: PMC3106356 DOI: 10.1155/2011/103039

Abstract

Orthosiphon stamineus as medicinal plant is commonly used in Malaysia for treatment of hepatitis and jaundice; in this study, the ethanol extracts were applied to evaluate the hepatoprotective effects in a thioacetamide-induced hepatotoxic model in Sprague Dawley rats. Five groups of adult rats were arranged as follows: Group 1 (normal control group), Group 2 Thioacetamide (TAA) as positive control (hepatotoxic group), Group 3 Silymarin as a well-known standard drug (hepatoprotective group), and Groups 4 and 5 as high and low dose (treatment groups). After 60-day treatment, all rats were sacrificed. The hepatotoxic group showed a coarse granulation on the liver surface when compared to the smooth aspect observed on the liver surface of the other groups. Histopathological study confirmed the result; moreover, there was a significant increase in serum liver biochemical parameters (ALT, AST, ALP, and Bilirubin) and the level of liver Malondialdehyde (MDA), accompanied by a significant decrease in the level of total protein and Albumin in the TAA control group when compared with that of the normal group. The high-dose treatment group (200 mg/kg) significantly restored the elevated liver function enzymes near to normal. This study revealed that 200 mg/kg extracts of O. stamineus exerted a hepatoprotective effect.

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