Display options
Cite
Utkan T, Yusuf S, Zafer UN, et al. The influence of experimental hyperthyroidism on responsiveness in rabbit aortic smooth muscle. Environ Toxicol Pharmacol. 1997;3(1):7-11doi: 10.1016/s1382-6689(96)00131-7.
Utkan, T., Yusuf, S., Zafer, U. N., & Kemal, Y. M. (1997). The influence of experimental hyperthyroidism on responsiveness in rabbit aortic smooth muscle. Environmental toxicology and pharmacology, 3(1), 7-11. https://doi.org/10.1016/s1382-6689(96)00131-7
Utkan, T, et al. "The influence of experimental hyperthyroidism on responsiveness in rabbit aortic smooth muscle." Environmental toxicology and pharmacology vol. 3,1 (1997): 7-11. doi: https://doi.org/10.1016/s1382-6689(96)00131-7
Utkan T, Yusuf S, Zafer UN, Kemal YM. The influence of experimental hyperthyroidism on responsiveness in rabbit aortic smooth muscle. Environ Toxicol Pharmacol. 1997 Feb 15;3(1):7-11. doi: 10.1016/s1382-6689(96)00131-7. PMID: 21781751.
Copy Download .nbib Format: NLM
Share it on

Environ Toxicol Pharmacol. 1997 Feb 15;3(1):7-11. doi: 10.1016/s1382-6689(96)00131-7.

The influence of experimental hyperthyroidism on responsiveness in rabbit aortic smooth muscle.

Environmental toxicology and pharmacology

T Utkan, S Yusuf, U N Zafer, Y M Kemal

Affiliations

  1. Department of Pharmacology and Toxicology, Faculty of Medicine, University of Kocaeli, 41900, Derince, Kocaeli, Turkey.

PMID: 21781751 DOI: 10.1016/s1382-6689(96)00131-7

Abstract

This study investigated the responsiveness of hyperthyroid and control (euthyroid) rabbit aortic rings to vasoconstrictor agents. There was no significant difference between the responsiveness of hyperthyroid and control tissues to KCl. Maximum responses (E(m)) to noradrenaline and serotonin were reduced in hyperthyroid rabbit aortic rings compared to those euthyroid rings. The sensitivity (i.e., EC(50)) of hyperthyroid aortic rings to noradrenaline and serotonin compared to euthyroid controls was unchanged. The K(b) value of prazosin against 10(-6) M noradrenaline-induced contractions in eu- and hyperthyroid states was 1.97 ± 0.59 · 10(-9) M and 1.92 ± 0.79 · 10(-9) M, respectively. The K(b) value of methisergide against 10(-6) M serotonin-induced contractions in eu- and hyperthyroid states was 1.46 ± 0.80 · 10(-9) M and 1.10 ± 0.16 · 10(-9) M, respectively. These data indicate that vascular reactivity is altered in experimental hyperthyroidism and this alteration, if any, do not occur at the receptor level.

Publication Types