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Jansen LA, de Vrije T, Koeman JH, et al. The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication. Environ Toxicol Pharmacol. 1997;3(1):13-6doi: 10.1016/s1382-6689(96)00132-9.
Jansen, L. A., de Vrije, T., Koeman, J. H., & Jongen, W. M. (1997). The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication. Environmental toxicology and pharmacology, 3(1), 13-6. https://doi.org/10.1016/s1382-6689(96)00132-9
Jansen, L A, et al. "The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication." Environmental toxicology and pharmacology vol. 3,1 (1997): 13-6. doi: https://doi.org/10.1016/s1382-6689(96)00132-9
Jansen LA, de Vrije T, Koeman JH, Jongen WM. The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication. Environ Toxicol Pharmacol. 1997 Feb 15;3(1):13-6. doi: 10.1016/s1382-6689(96)00132-9. PMID: 21781752.
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Environ Toxicol Pharmacol. 1997 Feb 15;3(1):13-6. doi: 10.1016/s1382-6689(96)00132-9.

The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication.

Environmental toxicology and pharmacology

L A Jansen, T de Vrije, J H Koeman, W M Jongen

Affiliations

  1. Agrotechnological Research Institute (ATO-DLO), Department of Food Safety, P.O.Box 17, 6700 AA Wageningen, The Netherlands; Agricultural University Wageningen, Department of Toxicology, Tuinlaan 5, 6703 HE Wageningen, The Netherlands.

PMID: 21781752 DOI: 10.1016/s1382-6689(96)00132-9

Abstract

The effect of several tumor promoters (12-O-tetradecanoyl-phorbol-13-acetate (TPA); 1,1'-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] (DDT); Aroclor1260, and clofibrate) on the inhibition of gap junctional intercellular communication (GJIC) and intracellular calcium concentration ([Ca(2+)](i)) was studied in a cell line consisting of initiated cells (3PC). In addition, the effect of different extracellular calcium concentrations ([Ca(2+)](e)) on the effects of tumor promoters on both GJIC and [Ca(2+)](i) were studied. Agents with GJIC inhibiting capacity increased [Ca(2+)](i). However, the increase of [Ca(2+)](i) did not (always) precede GJIC inhibition. The effect of tumor promoters on GJIC were similar under low (0.05 mM) and high (1.20 mM) Ca(2+)(e) conditions, while different effects on [Ca(2+)](i) were found. These results suggest that tumor promoters can inhibit GJIC and change [Ca(2+)](i), but that there is no direct relationship between these two processes.

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