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Coleman MD, Hayes PJ, Jacobus DP. Methaemoglobin formation due to nitrite, disulfiram, 4-aminophenol and monoacetyldapsone hydroxylamine in diabetic and non-diabetic human erythrocytes in vitro. Environ Toxicol Pharmacol. 1998;5(1):61-7doi: 10.1016/s1382-6689(97)10006-0.
Coleman, M. D., Hayes, P. J., & Jacobus, D. P. (1998). Methaemoglobin formation due to nitrite, disulfiram, 4-aminophenol and monoacetyldapsone hydroxylamine in diabetic and non-diabetic human erythrocytes in vitro. Environmental toxicology and pharmacology, 5(1), 61-7. https://doi.org/10.1016/s1382-6689(97)10006-0
Coleman, M D, et al. "Methaemoglobin formation due to nitrite, disulfiram, 4-aminophenol and monoacetyldapsone hydroxylamine in diabetic and non-diabetic human erythrocytes in vitro." Environmental toxicology and pharmacology vol. 5,1 (1998): 61-7. doi: https://doi.org/10.1016/s1382-6689(97)10006-0
Coleman MD, Hayes PJ, Jacobus DP. Methaemoglobin formation due to nitrite, disulfiram, 4-aminophenol and monoacetyldapsone hydroxylamine in diabetic and non-diabetic human erythrocytes in vitro. Environ Toxicol Pharmacol. 1998 Jan;5(1):61-7. doi: 10.1016/s1382-6689(97)10006-0. PMID: 21781851.
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Environ Toxicol Pharmacol. 1998 Jan;5(1):61-7. doi: 10.1016/s1382-6689(97)10006-0.

Methaemoglobin formation due to nitrite, disulfiram, 4-aminophenol and monoacetyldapsone hydroxylamine in diabetic and non-diabetic human erythrocytes in vitro.

Environmental toxicology and pharmacology

M D Coleman, P J Hayes, D P Jacobus

Affiliations

  1. Mechanisms of Drug Toxicity Group, Department of Pharmaceutical Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.

PMID: 21781851 DOI: 10.1016/s1382-6689(97)10006-0

Abstract

Nitrite, monoacetyl dapsone hydroxylamine, 4-aminophenol and disulfiram-mediated methaemoglobin formation was studied in human diabetic and non-diabetic erythrocytes in vitro. Diabetic intact erythrocytes were significantly less sensitive compared with those of non-diabetics to haemoglobin oxidation caused by the hydroxylamine, nitrite and 4-aminophenol, but not disulfiram. In haemolysates, differential sensitivity did occur with disulfiram and was partially retained with 4-aminophenol and nitrite. The differences were lost with 4-aminophenol, nitrite and disulfiram in the presence of haemoglobin purified from the respective erythrocyte types. Diethyl maleate reduced methaemoglobin formation in non-diabetic intact erythrocytes with 4-aminophenol, the hydroxylamine and disulfiram, but not with nitrite. Overall, the differential sensitivity to methaemoglobin formation seen in diabetic compared with non-diabetic erythrocytes, is probably linked to differences in the respective cells' cytosolic anti-oxidant systems.

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