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Ikeda M, Inukai N, Mitsui T, et al. Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats. Environ Toxicol Pharmacol. 2002;11(1):1-7doi: 10.1016/s1382-6689(01)00094-1.
Ikeda, M., Inukai, N., Mitsui, T., Sone, H., Yonemoto, J., Tohyama, C., & Tomita, T. (2002). Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats. Environmental toxicology and pharmacology, 11(1), 1-7. https://doi.org/10.1016/s1382-6689(01)00094-1
Ikeda, Masahiko, et al. "Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats." Environmental toxicology and pharmacology vol. 11,1 (2002): 1-7. doi: https://doi.org/10.1016/s1382-6689(01)00094-1
Ikeda M, Inukai N, Mitsui T, Sone H, Yonemoto J, Tohyama C, Tomita T. Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats. Environ Toxicol Pharmacol. 2002 Jan;11(1):1-7. doi: 10.1016/s1382-6689(01)00094-1. PMID: 21782580.
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Environ Toxicol Pharmacol. 2002 Jan;11(1):1-7. doi: 10.1016/s1382-6689(01)00094-1.

Changes in fetal brain aromatase activity following in utero 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure in rats.

Environmental toxicology and pharmacology

Masahiko Ikeda, Naomi Inukai, Tetsuo Mitsui, Hideko Sone, Junzo Yonemoto, Chiharu Tohyama, Takako Tomita

Affiliations

  1. University of Shizuoka, Graduate School of Health Sciences, 52-1, Yada, Shizuoka 422-8526, Japan; CREST, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan.

PMID: 21782580 DOI: 10.1016/s1382-6689(01)00094-1

Abstract

Aromatase catalyzes intraneuronal conversion of androgens to estrogens in the hypothalamus-preoptic area at a specific time during development. This local estrogen formation has a central role in sexual differentiation. To investigate the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on sexual differentiation, TCDD (800 and 1600 ng/kg) was orally administered to pregnant Holtzman rats on gestation day (GD) 15, and the change in brain aromatase activity of fetuses (GD20) and pups (postnatal day 2) was examined. Litter means of brain aromatase activity in the hypo-preoptic area of control fetuses were higher in males than in females (female/male ratio was 0.7). This ratio of aromatase activity increased in a TCDD-concentration dependent manner, reaching 1 at the higher dose. There was a similar change in aromatase activity in brains of pups (PND 2). These results suggest that in utero TCDD exposure induces demasculinization in male offspring by inhibiting the aromatase activity in the brain during central nervous system development.

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