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Vitalone A, Catalani A, Chiodi V, et al. Neurobehavioral assessment of rats exposed to low doses of PCB126 and methyl mercury during development. Environ Toxicol Pharmacol. 2007;25(1):103-13doi: 10.1016/j.etap.2007.09.006.
Vitalone, A., Catalani, A., Chiodi, V., Cinque, C., Fattori, V., Goldoni, M., Matteucci, P., Poli, D., Zuena, A. R., & Costa, L. G. (2008). Neurobehavioral assessment of rats exposed to low doses of PCB126 and methyl mercury during development. Environmental toxicology and pharmacology, 25(1), 103-13. https://doi.org/10.1016/j.etap.2007.09.006
Vitalone, Annabella, et al. "Neurobehavioral assessment of rats exposed to low doses of PCB126 and methyl mercury during development." Environmental toxicology and pharmacology vol. 25,1 (2008): 103-13. doi: https://doi.org/10.1016/j.etap.2007.09.006
Vitalone A, Catalani A, Chiodi V, Cinque C, Fattori V, Goldoni M, Matteucci P, Poli D, Zuena AR, Costa LG. Neurobehavioral assessment of rats exposed to low doses of PCB126 and methyl mercury during development. Environ Toxicol Pharmacol. 2008 Jan;25(1):103-13. doi: 10.1016/j.etap.2007.09.006. Epub 2007 Sep 26. PMID: 21783843.
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Environ Toxicol Pharmacol. 2008 Jan;25(1):103-13. doi: 10.1016/j.etap.2007.09.006. Epub 2007 Sep 26.

Neurobehavioral assessment of rats exposed to low doses of PCB126 and methyl mercury during development.

Environmental toxicology and pharmacology

Annabella Vitalone, Assia Catalani, Valentina Chiodi, Carlo Cinque, Vittorio Fattori, Matteo Goldoni, Patrizia Matteucci, Diana Poli, Anna Rita Zuena, Lucio G Costa

Affiliations

  1. Department of Human Anatomy, Pharmacology and Forensic Sciences, University of Parma Medical School, Parma, Via Volturno 39, 43100 Parma, Italy.

PMID: 21783843 DOI: 10.1016/j.etap.2007.09.006

Abstract

Epidemiological and laboratory studies have suggested that polychlorinated biphenyls (PCBs) and methyl mercury (MeHg) may have additive or synergistic effects on CNS function. Aim of this study was to characterize the effects of exposure to low levels of MeHg (0.5mg/kgday in drinking water) and PCB126 (100ng/kgday in food), alone and in combination, on neurobehavioral development in Wistar rats. Dams were treated from gestational day 7 to post-natal day (PND) 21. Animals were tested for developmental landmarks and reflexes (PND1-21), attention deficits (PND40), locomotor activity (PND30, 110), spatial learning (PND75), coordination and balance (PND90), object discrimination (PND80), anxiety (PND100), and conditioned learning (PND110). Parameters related to pregnancy, sex ratio at birth, and physical development (at weaning) did not differ among groups, though PCB126 decreased number of pups at birth. A slight delay in negative geotaxis was found in female rats in all treatment groups. No significant effects were seen in attention, coordination and balance, object discrimination, and spatial and conditioned learning. Increased motor activity was present in PCB126-treated male and in MeHg+PCB-treated female rats in the elevated plus maze test, and in PCB126-treated male rats in the open field test (PND110). The results do not support the hypothesis that co-exposure to MeHg and PCB126 results in additive or synergistic effects. This finding is in agreement with more recent in vitro and in vivo studies.

Copyright © 2007 Elsevier B.V. All rights reserved.

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