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D'Orso I, Frankel AD. HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear. Viruses. 2010;2(10):2226-2234doi: 10.3390/v2102226.
D'Orso, I., & Frankel, A. D. (2010). HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear. Viruses, 2(10), 2226-2234. https://doi.org/10.3390/v2102226
D'Orso, Iván, and Frankel, Alan D. "HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear." Viruses vol. 2,10 (2010): 2226-2234. doi: https://doi.org/10.3390/v2102226
D'Orso I, Frankel AD. HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear. Viruses. 2010 Oct 01;2(10):2226-2234. doi: 10.3390/v2102226. PMID: 21709748; PMCID: PMC3120229.
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Viruses. 2010 Oct 01;2(10):2226-2234. doi: 10.3390/v2102226.

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear.

Viruses

Iván D'Orso, Alan D Frankel

Affiliations

  1. Department of Biochemistry and Biophysics, University of California, 600 16 Street, San Francisco, CA 94158-2280.

PMID: 21709748 PMCID: PMC3120229 DOI: 10.3390/v2102226

Abstract

HIV-1 transcription is regulated at the level of elongation by the viral Tat protein together with the cellular elongation factor P-TEFb, which is composed of cyclin T1 and Cdk9 subunits. The crystal structure of a Tat:P-TEFb complex (Tahirov, T.H.; Babayeva, N.D.; Varzavand, K.; Cooper, J.J.; Sedore, S.C.; and Price, D.H. Crystal structure of HIV-1 Tat complexed with human P-TEFb. Nature2010, 465, 747-751) reveals molecular details of Tat and its interactions that have eluded investigators for more than two decades and provides provocative insights into the mechanism of Tat activation.

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