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Bushey JM, Kaplan DA, Danell RM, et al. Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary. Instrum Sci Technol. 2009;37(3):257-273doi: 10.1080/10739140902831313.
Bushey, J. M., Kaplan, D. A., Danell, R. M., & Glish, G. L. (2009). Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary. Instrumentation science & technology, 37(3), 257-273. https://doi.org/10.1080/10739140902831313
Bushey, Jared M, et al. "Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary." Instrumentation science & technology vol. 37,3 (2009): 257-273. doi: https://doi.org/10.1080/10739140902831313
Bushey JM, Kaplan DA, Danell RM, Glish GL. Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary. Instrum Sci Technol. 2009;37(3):257-273. doi: 10.1080/10739140902831313. PMID: 21785563; PMCID: PMC3141176.
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Instrum Sci Technol. 2009;37(3):257-273. doi: 10.1080/10739140902831313.

Pulsed Nano-Electrospray Ionization: Characterization of Temporal Response and Implementation with a Flared Inlet Capillary.

Instrumentation science & technology

Jared M Bushey, Desmond A Kaplan, Ryan M Danell, Gary L Glish

Affiliations

  1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-3290, USA.

PMID: 21785563 PMCID: PMC3141176 DOI: 10.1080/10739140902831313

Abstract

The temporal response of pulsed nano-electrospray ionization mass spectrometry (nano-ESI-MS) was studied and its influence on ion formation and detection was characterized. Rise and decay times for the mass resolved ion current were determined to be 20 ± 3 msec and 61 ± 5 msec, respectively, which led to a maximum pulse rate of 12 Hz. Pulsed nano-ESI operation was demonstrated from a multi-sprayer source controlled by a high voltage pulsing circuit constructed in-house. The desired source mode of operation (e.g. pulsing or continuous) can be realized solely by controlling the voltage applied to each sprayer.

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