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Stepien KM, Prinsloo P, Hitch T, et al. Acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient. Int J Nephrol. 2011;2011:679160doi: 10.4061/2011/679160.
Stepien, K. M., Prinsloo, P., Hitch, T., McCulloch, T. A., & Sims, R. (2011). Acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient. International journal of nephrology, 2011679160. https://doi.org/10.4061/2011/679160
Stepien, Karolina M, et al. "Acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient." International journal of nephrology vol. 2011 (2011): 679160. doi: https://doi.org/10.4061/2011/679160
Stepien KM, Prinsloo P, Hitch T, McCulloch TA, Sims R. Acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient. Int J Nephrol. 2011;2011:679160. doi: 10.4061/2011/679160. Epub 2011 Jul 19. PMID: 21785726; PMCID: PMC3140202.
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Int J Nephrol. 2011;2011:679160. doi: 10.4061/2011/679160. Epub 2011 Jul 19.

Acute renal failure, microangiopathic haemolytic anemia, and secondary oxalosis in a young female patient.

International journal of nephrology

Karolina M Stepien, Peter Prinsloo, Tony Hitch, Thomas A McCulloch, Rebecca Sims

Affiliations

  1. Clinical Pathology Department, Nottingham University Hospitals Trust, Nottingham NG5 1PB, UK.

PMID: 21785726 PMCID: PMC3140202 DOI: 10.4061/2011/679160

Abstract

A 29-year old female presented with a one-week history of vomiting, diarrhoea, abdominal pain, and headache. On admission, she had acute renal failure requiring dialysis. Tests revealed a hemolytic anemia with thrombocytopenia. An initial diagnosis of thrombotic thrombocytopenic microangiopathy was made and plasma exchange was instigated. However, renal biopsy did not show thrombotic microangiopathy but instead revealed acute kidney injury with mild tubulointerstitial nephritis and numerous oxalate crystals, predominantly in the distal tubules. The patient had been taking large doses (>1100 mg daily) of vitamin C for many months. She also gave a history of sclerotherapy using injections of an ethylene glycol derivative for superficial leg veins. The patient completed five sessions of plasma exchange and was able to discontinue dialysis. She eventually achieved full renal recovery. She has now discontinued sclerotherapy and vitamin supplementation.

References

  1. Dermatol Surg. 1995 Apr;21(4):334-6; discussion 337-8 - PubMed
  2. Chest. 2000 Aug;118(2):561-3 - PubMed
  3. Am J Transplant. 2006 Oct;6(10):2516-21 - PubMed
  4. Kidney Int. 2006 Nov;70(10):1672 - PubMed
  5. Dermatol Surg. 2010 Jun;36 Suppl 2:1056-1063 - PubMed
  6. J Am Soc Nephrol. 1996 Nov;7(11):2320-6 - PubMed
  7. Lancet. 1990 Oct 13;336(8720):944 - PubMed
  8. J Obstet Gynaecol Br Commonw. 1967 Oct;74(5):702-11 - PubMed
  9. Lancet. 1994 Feb 5;343(8893):357 - PubMed
  10. Clin Pharmacokinet. 1990 Jun;18(6):472-84 - PubMed
  11. Arch Toxicol. 2004 Dec;78(12):697-705 - PubMed
  12. BMJ. 1993 Mar 27;306(6881):841-2 - PubMed
  13. Expert Opin Investig Drugs. 2009 Dec;18(12):1919-27 - PubMed
  14. Lancet. 1973 Jun 30;1(7818):1479-81 - PubMed
  15. Dermatol Surg. 2000 Apr;26(4):323-8 - PubMed
  16. ASAIO Trans. 1990 Jul-Sep;36(3):M597-9 - PubMed
  17. Br Med J (Clin Res Ed). 1981 Dec 5;283(6305):1547 - PubMed
  18. Drug Saf. 1993 Jul;9(1):21-37 - PubMed
  19. Rev Fr Gynecol Obstet. 1986 Dec;81(12):721-5 - PubMed
  20. Kidney Int. 2001 Jan;59(1):270-6 - PubMed
  21. Obstet Gynecol. 1972 Nov;40(5):681-5 - PubMed
  22. J Med Case Rep. 2007 Nov 27;1:155 - PubMed

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