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Cavalli R, Bisazza A, Bussano R, et al. Poly(amidoamine)-Cholesterol Conjugate Nanoparticles Obtained by Electrospraying as Novel Tamoxifen Delivery System. J Drug Deliv. 2011;2011:587604doi: 10.1155/2011/587604.
Cavalli, R., Bisazza, A., Bussano, R., Trotta, M., Civra, A., Lembo, D., Ranucci, E., & Ferruti, P. (2011). Poly(amidoamine)-Cholesterol Conjugate Nanoparticles Obtained by Electrospraying as Novel Tamoxifen Delivery System. Journal of drug delivery, 2011587604. https://doi.org/10.1155/2011/587604
Cavalli, R, et al. "Poly(amidoamine)-Cholesterol Conjugate Nanoparticles Obtained by Electrospraying as Novel Tamoxifen Delivery System." Journal of drug delivery vol. 2011 (2011): 587604. doi: https://doi.org/10.1155/2011/587604
Cavalli R, Bisazza A, Bussano R, Trotta M, Civra A, Lembo D, Ranucci E, Ferruti P. Poly(amidoamine)-Cholesterol Conjugate Nanoparticles Obtained by Electrospraying as Novel Tamoxifen Delivery System. J Drug Deliv. 2011;2011:587604. doi: 10.1155/2011/587604. Epub 2011 Jun 07. PMID: 21785731; PMCID: PMC3138208.
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J Drug Deliv. 2011;2011:587604. doi: 10.1155/2011/587604. Epub 2011 Jun 07.

Poly(amidoamine)-Cholesterol Conjugate Nanoparticles Obtained by Electrospraying as Novel Tamoxifen Delivery System.

Journal of drug delivery

R Cavalli, A Bisazza, R Bussano, M Trotta, A Civra, D Lembo, E Ranucci, P Ferruti

Affiliations

  1. Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Via P. Giuria 9, 10125 Torino, Italy.

PMID: 21785731 PMCID: PMC3138208 DOI: 10.1155/2011/587604

Abstract

A new poly(amidoamine)-cholesterol (PAA-cholesterol) conjugate was synthesized, characterized and used to produce nanoparticles by the electrospraying technique. The electrospraying is a method of liquid atomization that consists in the dispersion of a solution into small charged droplets by an electric field. Tuning the electrospraying process parameters spherical PAA-chol nanoparticles formed. The PAA-cholesterol nanoparticles showed sizes lower than 500 nm and spherical shape. The drug incorporation capacity was investigated using tamoxifen, a lipophilic anticancer drug, as model drug. The incorporation of the tamoxifen did not affect the shape and sizes of nanoparticles showing a drug loading of 40%. Tamoxifen-loaded nanoparticles exhibited a higher dose-dependent cytotoxicity than free tamoxifen, while blank nanoparticles did not show any cytotoxic effect at the same concentrations. The electrospray technique might be proposed to produce tamoxifen-loaded PAA-chol nanoparticle in powder form without any excipient in a single step.

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