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Ksouda K, Affes H, Hammami B, et al. Ageusia as a side effect of clopidogrel treatment. Indian J Pharmacol. 2011;43(3):350-1doi: 10.4103/0253-7613.81498.
Ksouda, K., Affes, H., Hammami, B., Sahnoun, Z., Atheymen, R., Hammami, S., & Zeghal, K. M. (2011). Ageusia as a side effect of clopidogrel treatment. Indian journal of pharmacology, 43(3), 350-1. https://doi.org/10.4103/0253-7613.81498
Ksouda, Kamilia, et al. "Ageusia as a side effect of clopidogrel treatment." Indian journal of pharmacology vol. 43,3 (2011): 350-1. doi: https://doi.org/10.4103/0253-7613.81498
Ksouda K, Affes H, Hammami B, Sahnoun Z, Atheymen R, Hammami S, Zeghal KM. Ageusia as a side effect of clopidogrel treatment. Indian J Pharmacol. 2011 May;43(3):350-1. doi: 10.4103/0253-7613.81498. PMID: 21713046; PMCID: PMC3113393.
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Indian J Pharmacol. 2011 May;43(3):350-1. doi: 10.4103/0253-7613.81498.

Ageusia as a side effect of clopidogrel treatment.

Indian journal of pharmacology

Kamilia Ksouda, Hanen Affes, Boutheyna Hammami, Zouheir Sahnoun, Rim Atheymen, Serria Hammami, Khaled Mounir Zeghal

Affiliations

  1. Department of Pharmacology, Faculty of Medicine of Sfax, Tunisia.

PMID: 21713046 PMCID: PMC3113393 DOI: 10.4103/0253-7613.81498

Abstract

Clopidogrel is prescribed in cardiac and extracardiac vascular diseases. It is generally well tolerated; however, few cases of taste disorders have been reported. We present a case of clopidogrel-induced ageusia notified in Sfax pharmacovigilance center on March 13, 2009. A 46-year-old patient developed ageusia with decreased appetite five weeks after starting clopidogrel. Other etiologies including ear nose throat (ENT) examination were ruled out. Five months after reduction of clopidogrel dose, ageusia partially decreased. Clopidogrel was strongly suspected as a causal drug. According to the French imputation method, score of imputability was considered as plausible (C2S2) I2. Physiopathology of this side effect is not yet understood. However, it seems to be a reversible and dose-related event. Although it is not life-threatening, loss of taste can have significant effect on the quality of life of patients.

Keywords: Ageusia; clopidogrel; taste disorders

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