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Nassar MI, Aboutabl el-SA, Ahmed RF, et al. Secondary metabolites and bioactivities of Myrtus communis. Pharmacognosy Res. 2010;2(6):325-9doi: 10.4103/0974-8490.75449.
Nassar, M. I., Aboutabl, e. l. -. S. A., Ahmed, R. F., El-Khrisy, E. D., Ibrahim, K. M., & Sleem, A. A. (2010). Secondary metabolites and bioactivities of Myrtus communis. Pharmacognosy research, 2(6), 325-9. https://doi.org/10.4103/0974-8490.75449
Nassar, Mahmoud I, et al. "Secondary metabolites and bioactivities of Myrtus communis." Pharmacognosy research vol. 2,6 (2010): 325-9. doi: https://doi.org/10.4103/0974-8490.75449
Nassar MI, Aboutabl el-SA, Ahmed RF, El-Khrisy ED, Ibrahim KM, Sleem AA. Secondary metabolites and bioactivities of Myrtus communis. Pharmacognosy Res. 2010 Nov;2(6):325-9. doi: 10.4103/0974-8490.75449. PMID: 21713133; PMCID: PMC3111689.
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Pharmacognosy Res. 2010 Nov;2(6):325-9. doi: 10.4103/0974-8490.75449.

Secondary metabolites and bioactivities of Myrtus communis.

Pharmacognosy research

Mahmoud I Nassar, El-Sayed A Aboutabl, Rania F Ahmed, Ezzel-Din A El-Khrisy, Khaled M Ibrahim, Amany A Sleem

Affiliations

  1. Department of Chemistry of Natural Compounds, Dokki, Cairo, Egypt.

PMID: 21713133 PMCID: PMC3111689 DOI: 10.4103/0974-8490.75449

Abstract

BACKGROUND: Myrtus species are characterized by the presence of phenolic acids, flavonoids, tannins, volatile oils and fatty acids. They are remedies for variety of ailments. This study therefore investigated medicinal effects of Myrtus communis L.

METHODS: Bioactivity studies of Myrtus communis L. leaves were carried out on volatile oil, 7% methanol and aqueous extracts and the isolated compounds myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid.

RESULTS: Determination of the median lethal dose (LD(50)) revealed that the volatile oil, alcoholic and aqueous extracts were practically nontoxic and highly safe as no lethality was observed. The tested materials (volatile oil, alcoholic and aqueous extracts, myricetin 3-O-β-glucopyranoside, myricetin 3-O-∝-rhamnopyranoside and gallic acid) showed significant antihyperglycemic, anti-inflammatory and antinociceptive effects as compared with control groups and reference drugs.

CONCLUSION: Administration of extracts of M. communis leaves could be safe at the dose used in this study.

Keywords: Antihyperglycemic; LD50; Myrtus communis; Volatile oil; anti-inflammatory; antinociceptive

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