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Chen X, Shen Y, Xiang W. Distribution Characteristics of Hepatitis B Serological Markers in Hospitalized Children and Adolescents in Zhejiang, China between 2006 and 2010. Gut Liver. 2011;5(2):210-6doi: 10.5009/gnl.2011.5.2.210.
Chen, X., Shen, Y., & Xiang, W. (2011). Distribution Characteristics of Hepatitis B Serological Markers in Hospitalized Children and Adolescents in Zhejiang, China between 2006 and 2010. Gut and liver, 5(2), 210-6. https://doi.org/10.5009/gnl.2011.5.2.210
Chen, Xuejun, et al. "Distribution Characteristics of Hepatitis B Serological Markers in Hospitalized Children and Adolescents in Zhejiang, China between 2006 and 2010." Gut and liver vol. 5,2 (2011): 210-6. doi: https://doi.org/10.5009/gnl.2011.5.2.210
Chen X, Shen Y, Xiang W. Distribution Characteristics of Hepatitis B Serological Markers in Hospitalized Children and Adolescents in Zhejiang, China between 2006 and 2010. Gut Liver. 2011 Jun;5(2):210-6. doi: 10.5009/gnl.2011.5.2.210. Epub 2011 Jun 23. PMID: 21814603; PMCID: PMC3140668.
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Gut Liver. 2011 Jun;5(2):210-6. doi: 10.5009/gnl.2011.5.2.210. Epub 2011 Jun 23.

Distribution Characteristics of Hepatitis B Serological Markers in Hospitalized Children and Adolescents in Zhejiang, China between 2006 and 2010.

Gut and liver

Xuejun Chen, Yuefang Shen, Wenqing Xiang

Affiliations

  1. Department of Clinical Laboratory, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.

PMID: 21814603 PMCID: PMC3140668 DOI: 10.5009/gnl.2011.5.2.210

Abstract

BACKGROUND/AIMS: To investigate serological patterns of hepatitis B based on electrochemiluminescent immunoassays and the distribution characteristics of these patterns in hospitalized children and adolescents in Zhejiang, China between 2006 and 2010.

METHODS: Five serological markers, including hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), antibody to hepatitis B surface antigen (anti-HBs), antibody to hepatitis B e antigen (anti-HBe), and antibody to hepatitis B c antigen (anti-HBc), were chosen as a routine panel to monitor hepatitis B virus (HBV) infection and vaccination efficacy. A total of 33,187 children (21,187 boys and 12,000 girls) were selected using the following exclusion criteria: a previous diagnosis of hepatitis, age >16 years or an address outside of Zhejiang.

RESULTS: The average HBV vaccination coverage rates among 20,766 boys and 11,782 girls were 98.62% and 98.68%, respectively. Seventeen serological patterns of hepatitis B were found, and the dominant pattern was 'anti-HBs (+) alone' (62.03%) followed by 'negative pattern' (23.46%). The rates of the other 15 patterns ranged from 8.14% to 0.003%. Of 236 HBsAg-positive patients, the overall rate of seropositivity was 0.71%. The anti-HBs levels were grouped into 3 ranges (10-100 mIU/mL, 100-1,000 mIU/mL, and >1,000 mIU/mL) for all anti-HBs-positive children (36.08%, 43.43%, and 20.49%, respectively).

CONCLUSIONS: A low HBsAg carrier rate and a relatively high anti-HBs positive rate are present in hospitalized children and adolescents in Zhejiang. The distribution of serological patterns is associated with age but is mostly independent of gender.

Keywords: Chemiluminescent measurements; Children; Epidemiologic studies; Hepatitis B antibodies; Immunoassay

References

  1. Zhongguo Yi Miao He Mian Yi. 2009 Apr;15(2):159-62 - PubMed
  2. Am J Trop Med Hyg. 2010 Jul;83(1):189-93 - PubMed
  3. Chin Med J (Engl). 2009 Jan 5;122(1):98-102 - PubMed
  4. Acta Paediatr. 2003 Oct;92(10):1158-62 - PubMed
  5. J Med Virol. 2003 Nov;71(3):360-6 - PubMed
  6. Korean J Lab Med. 2007 Oct;27(5):355-9 - PubMed
  7. Clin Diagn Lab Immunol. 2000 Nov;7(6):865-6 - PubMed
  8. J Infect Dis. 2009 Jul 1;200(1):39-47 - PubMed
  9. Breastfeed Med. 2010 Jun;5(3):109-12 - PubMed
  10. Vaccine. 2009 Nov 5;27(47):6613-8 - PubMed
  11. Chin Med J (Engl). 2009 Jan 5;122(1):3-4 - PubMed
  12. J Clin Virol. 2003 Jul;27(2):162-9 - PubMed
  13. Niger J Med. 2007 Oct-Dec;16(4):326-9 - PubMed
  14. Clin Chem. 1994 Nov;40(11 Pt 1):2042-5 - PubMed
  15. Vaccine. 1993;11(9):941-5 - PubMed
  16. Acta Paediatr. 1996 Dec;85(12):1501-2 - PubMed
  17. Curr Clin Top Infect Dis. 1992;12:282-308 - PubMed
  18. Trop Gastroenterol. 1995 Oct-Dec;16(4):4-10 - PubMed
  19. N Engl J Med. 2004 Dec 30;351(27):2832-8 - PubMed
  20. J Clin Gastroenterol. 2004 Nov-Dec;38(10 Suppl 3):S158-68 - PubMed
  21. World J Gastroenterol. 2006 Feb 28;12(8):1255-60 - PubMed
  22. J Med Virol. 2009 Sep;81(9):1517-24 - PubMed
  23. J Infect Dev Ctries. 2010 Mar 29;4(3):168-70 - PubMed
  24. Vaccine. 2009 Nov 5;27(47):6550-7 - PubMed
  25. Am J Clin Pathol. 1981 Dec;76(6):773-7 - PubMed

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