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Small GTPases. 2011 May;2(3):182-186. doi: 10.4161/sgtp.2.3.16701.

Rab GTPases and tethering in the yeast endocytic pathway.

Small GTPases

Jens Lachmann, Christian Ungermann, Siegfried Engelbrecht-Vandré

Affiliations

  1. Department of Biology/Chemistry; Biochemistry Section; University of Osnabrück; Osnabrück, Germany.

PMID: 21776422 PMCID: PMC3136951 DOI: 10.4161/sgtp.2.3.16701

Abstract

Within eukaryotic cells, Rab GTPases control the maturation of early to late endosomes and their subsequent fusion with the vacuole. Within this ExtraView, we will focus on our recent findings regarding the activation of the Rab7 homolog Ypt7 in yeast and its interplay with the two multisubunit tethering complexes CORVET and HOPS.

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