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Cervera MI, Beltran J, Lopez FJ, et al. Determination of volatile organic compounds in water by headspace solid-phase microextraction gas chromatography coupled to tandem mass spectrometry with triple quadrupole analyzer. Anal Chim Acta. 2011;704(1):87-97doi: 10.1016/j.aca.2011.08.012.
Cervera, M. I., Beltran, J., Lopez, F. J., & Hernandez, F. (2011). Determination of volatile organic compounds in water by headspace solid-phase microextraction gas chromatography coupled to tandem mass spectrometry with triple quadrupole analyzer. Analytica chimica acta, 704(1), 87-97. https://doi.org/10.1016/j.aca.2011.08.012
Cervera, M I, et al. "Determination of volatile organic compounds in water by headspace solid-phase microextraction gas chromatography coupled to tandem mass spectrometry with triple quadrupole analyzer." Analytica chimica acta vol. 704,1 (2011): 87-97. doi: https://doi.org/10.1016/j.aca.2011.08.012
Cervera MI, Beltran J, Lopez FJ, Hernandez F. Determination of volatile organic compounds in water by headspace solid-phase microextraction gas chromatography coupled to tandem mass spectrometry with triple quadrupole analyzer. Anal Chim Acta. 2011 Oct 17;704(1):87-97. doi: 10.1016/j.aca.2011.08.012. Epub 2011 Aug 11. PMID: 21907025.
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Anal Chim Acta. 2011 Oct 17;704(1):87-97. doi: 10.1016/j.aca.2011.08.012. Epub 2011 Aug 11.

Determination of volatile organic compounds in water by headspace solid-phase microextraction gas chromatography coupled to tandem mass spectrometry with triple quadrupole analyzer.

Analytica chimica acta

M I Cervera, J Beltran, F J Lopez, F Hernandez

Affiliations

  1. Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain.

PMID: 21907025 DOI: 10.1016/j.aca.2011.08.012

Abstract

In the present work, a rapid method with little sample handling has been developed for determination of 23 selected volatile organic compounds in environmental and wastewater samples. The method is based on headspace solid-phase microextraction (SPME) followed by gas chromatography coupled to tandem mass spectrometry (GC-MS/MS) determination using triple quadrupole analyzer (QqQ) in electron ionization mode. The best conditions for extraction were optimised with a factorial design taking into account the interaction between different parameters and not only individual effects of variables. In the optimized procedure, 4 mL of water sample were extracted using a 10 mL vial and adding 0.4 g NaCl (final NaCl content of 10%). An SPME extraction with carboxen/polydimethylsiloxane 75 μm fiber for 30 min at 50°C (with 5 min of previous equilibration time) with magnetic stirring was applied. Chromatographic determination was carried out by GC-MS/MS working in Selected Reaction Monitoring (SRM) mode. For most analytes, two MS/MS transitions were acquired, although for a few compounds it was difficult to obtain characteristic abundant fragments. In those cases, a pseudo selected reaction monitoring (pseudo-SRM) with three ions was used instead. The intensity ratio between quantitation (Q) and confirmation (q) signals was used as a confirmatory parameter. The method was validated by means of recovery experiments (n=6) spiking mineral water samples at three concentration levels (0.1, 5 and 50 μg L(-1)). Recoveries between 70% and 120% were generally obtained with relative standard deviations (RSDs) lower than 20%. The developed method was applied to surface water and wastewater from a wastewater treatment plant and from a municipal solid-waste treatment plant. Several compounds, like chloroform, benzene, trichloroethylene, toluene, tetrachloroethylene, dibromochloromethane, xylenes and bromoform were detected and confirmed in all the samples analyzed.

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