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Kleger A, Liebau S, Lin Q, et al. The impact of bioactive lipids on cardiovascular development. Stem Cells Int. 2011;2011:916180doi: 10.4061/2011/916180.
Kleger, A., Liebau, S., Lin, Q., von Wichert, G., & Seufferlein, T. (2011). The impact of bioactive lipids on cardiovascular development. Stem cells international, 2011916180. https://doi.org/10.4061/2011/916180
Kleger, Alexander, et al. "The impact of bioactive lipids on cardiovascular development." Stem cells international vol. 2011 (2011): 916180. doi: https://doi.org/10.4061/2011/916180
Kleger A, Liebau S, Lin Q, von Wichert G, Seufferlein T. The impact of bioactive lipids on cardiovascular development. Stem Cells Int. 2011;2011:916180. doi: 10.4061/2011/916180. Epub 2011 Aug 02. PMID: 21876704; PMCID: PMC3159013.
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Stem Cells Int. 2011;2011:916180. doi: 10.4061/2011/916180. Epub 2011 Aug 02.

The impact of bioactive lipids on cardiovascular development.

Stem cells international

Alexander Kleger, Stefan Liebau, Qiong Lin, Götz von Wichert, Thomas Seufferlein

Affiliations

  1. Department of Internal Medicine I, University of Ulm, 89081 Ulm, Germany.

PMID: 21876704 PMCID: PMC3159013 DOI: 10.4061/2011/916180

Abstract

Lysophospholipids comprise a group of bioactive molecules with multiple biological functions. The cardinal members of this signalling molecule group are sphingosylphosphorylcholine (SPC), lysophosphatidic acid (LPA), and sphingosine 1-phosphate (S1P) which are, at least in part, homologous to each other. Bioactive lipids usually act via G-protein coupled receptors (GPCRs), but can also function as direct intracellular messengers. Recently, it became evident that bioactive lipids play a role during cellular differentiation development. SPC induces mesodermal differentiation of mouse ES cells and differentiation of promyelocytic leukemia cells, by a mechanism being critically dependent on MEK-ERK signalling. LPA stimulates the clonal expansion of neurospheres from neural stem/progenitor cells and induces c-fos via activation of mitogen- and stress-activated protein kinase 1 (MSK1) in ES cells. S1P acts on hematopoietic progenitor cells as a chemotactic factor and has also been found to be critical for cardiac and skeletal muscle regeneration. Furthermore, S1P promotes cardiogenesis and similarly activates Erk signalling in mouse ES cells. Interestingly, S1P may also act to maintain human stem cell pluripotency. Both LPA and S1P positively regulate the proliferative capacity of murine ES cells. In this paper we will focus on the differential and developmental impact of lysophospholipids on cardiovascular development.

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