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Rasoli S, Kakouros N, Harling L, et al. Antioxidant vitamins in the prevention of atrial fibrillation: what is the evidence?. Cardiol Res Pract. 2011;2011:164078doi: 10.4061/2011/164078.
Rasoli, S., Kakouros, N., Harling, L., Gukop, P., Soni, M., Athanasiou, T., & Kourliouros, A. (2011). Antioxidant vitamins in the prevention of atrial fibrillation: what is the evidence?. Cardiology research and practice, 2011164078. https://doi.org/10.4061/2011/164078
Rasoli, Sonia, et al. "Antioxidant vitamins in the prevention of atrial fibrillation: what is the evidence?." Cardiology research and practice vol. 2011 (2011): 164078. doi: https://doi.org/10.4061/2011/164078
Rasoli S, Kakouros N, Harling L, Gukop P, Soni M, Athanasiou T, Kourliouros A. Antioxidant vitamins in the prevention of atrial fibrillation: what is the evidence?. Cardiol Res Pract. 2011;2011:164078. doi: 10.4061/2011/164078. Epub 2011 Aug 23. PMID: 21876823; PMCID: PMC3162973.
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Cardiol Res Pract. 2011;2011:164078. doi: 10.4061/2011/164078. Epub 2011 Aug 23.

Antioxidant vitamins in the prevention of atrial fibrillation: what is the evidence?.

Cardiology research and practice

Sonia Rasoli, Nicholaos Kakouros, Leanne Harling, Philemon Gukop, Manish Soni, Thanos Athanasiou, Antonios Kourliouros

Affiliations

  1. Department of Cardiothoracic Surgery, St George's Hospital, London SW17 0QT, UK.

PMID: 21876823 PMCID: PMC3162973 DOI: 10.4061/2011/164078

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia that is associated with significant morbidity and mortality. Current available therapies remain inadequate in symptom control and secondary prevention and are often associated with significant side effects. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. Recently, increasing evidence implicates oxidative stress and inflammation in the pathogenesis of AF. We searched the literature for evidence to support the use of antioxidant vitamins C and E in the prevention of AF. These vitamins, through their reactive-oxygen-species- (ROS-) scavenging effect, have shown a role in AF prevention in both animal and small clinical studies. The available evidence, however, is currently insufficient to support recommendations for their use in the wider patient population. Larger-scale clinical studies are required to confirm these preliminary results. Research is also required to further the understanding of the processes involved in the pathogenesis of AF and the role of antioxidant therapies to prevent the arrhythmia.

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