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Barbado J, Vega L, González-Gallego R, et al. MCP-1 en orina como biomarcador de lupus renal en ausencia de citoquinas, interferón-γ y factores de crecimiento. [MCP-1 in urine as biomarker of renal lupus in absence of cytokines, interferon-γ and growth factors]. Reumatol Clin. 2010;6(6):296-8doi: 10.1016/j.reuma.2009.09.015.
Barbado, J., Vega, L., González-Gallego, R., Jimeno, A., Ortiz De Lejarazu, R., & Bermejo-Martin, J. F. (2010). MCP-1 en orina como biomarcador de lupus renal en ausencia de citoquinas, interferón-γ y factores de crecimiento. [MCP-1 in urine as biomarker of renal lupus in absence of cytokines, interferon-γ and growth factors]. Reumatologia clinica, 6(6), 296-8. https://doi.org/10.1016/j.reuma.2009.09.015
Barbado, Julia, et al. "MCP-1 en orina como biomarcador de lupus renal en ausencia de citoquinas, interferón-γ y factores de crecimiento." [MCP-1 in urine as biomarker of renal lupus in absence of cytokines, interferon-γ and growth factors]. Reumatologia clinica vol. 6,6 (2010): 296-8. doi: https://doi.org/10.1016/j.reuma.2009.09.015
Barbado J, Vega L, González-Gallego R, Jimeno A, Ortiz De Lejarazu R, Bermejo-Martin JF. MCP-1 en orina como biomarcador de lupus renal en ausencia de citoquinas, interferón-γ y factores de crecimiento. [MCP-1 in urine as biomarker of renal lupus in absence of cytokines, interferon-γ and growth factors]. Reumatol Clin. 2010 Nov-Dec;6(6):296-8. doi: 10.1016/j.reuma.2009.09.015. Epub 2010 Jun 08. Spanish. PMID: 21794736.
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Reumatol Clin. 2010 Nov-Dec;6(6):296-8. doi: 10.1016/j.reuma.2009.09.015. Epub 2010 Jun 08.

[MCP-1 in urine as biomarker of renal lupus in absence of cytokines, interferon-γ and growth factors].

Reumatologia clinica

[Article in Spanish]
Julia Barbado, Luisa Vega, Rocío González-Gallego, Antonio Jimeno, Raúl Ortiz De Lejarazu, Jesús F Bermejo-Martin

Affiliations

  1. Unidad de Enfermedades Autoinmunes, Servicio de Medicina Interna, Hospital Clínico Universitario, Valladolid, España.

PMID: 21794736 DOI: 10.1016/j.reuma.2009.09.015

Abstract

OBJECTIVE: To characterize 17 immunological markers in the Urine of patients with SLE.

INTRODUCTION: Lupus nephritis is an inflammatory disease affecting the renal parenchyma. Cytokines and chemokines are key immune mediators that have been related with the pathogenesis of the disease. Obtaining non invasive prognosis markers is a highly desirable objective in order to improve the clinical management of these patients.

PATIENTS AND METHODS: In this study we profiled 17 immune mediators (Th1, Th2, Th17 cytokines, chemokines and growth factors) in the urine of 25 patients with systemic lupus erythematosus with active renal disease by using a Biorad© 17-plex kit on a Luminex© platform. A group of healthy volunteers of similar age and comparable sex distribution was recruited as control (n=10).

RESULTS: Results evidenced that the only detectable mediators in urine were IL-8, MCP-1 and MIP-1 β. When levels of these mediators were compared between patients and controls, significantly higher levels of MCP-1 were observed in the urine of the patients. MCP-1 levels in urine correlated positively with the SLEDAI score in a significant way and negatively with plasma levels of complement C4.

CONCLUSIONS: Our results reinforce the role of MCP-1 in urine as biomarker of disease activity in renal lupus, excluding the detection of other soluble immune mediators such as Th1, Th2 ,Th17 cytokines and growth factors as suitable markers in this non invasive sample.

Copyright © 2009 Elsevier España, S.L. All rights reserved.

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