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Barger JL, Kayo T, Pugh TD, et al. Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse. Genes Nutr. 2011;7(2):155-65doi: 10.1007/s12263-011-0243-9.
Barger, J. L., Kayo, T., Pugh, T. D., Vann, J. A., Power, R., Dawson, K., Weindruch, R., & Prolla, T. A. (2012). Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse. Genes & nutrition, 7(2), 155-65. https://doi.org/10.1007/s12263-011-0243-9
Barger, Jamie L, et al. "Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse." Genes & nutrition vol. 7,2 (2012): 155-65. doi: https://doi.org/10.1007/s12263-011-0243-9
Barger JL, Kayo T, Pugh TD, Vann JA, Power R, Dawson K, Weindruch R, Prolla TA. Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse. Genes Nutr. 2012 Apr;7(2):155-65. doi: 10.1007/s12263-011-0243-9. Epub 2011 Aug 17. PMID: 21847681; PMCID: PMC3316740.
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Genes Nutr. 2012 Apr;7(2):155-65. doi: 10.1007/s12263-011-0243-9. Epub 2011 Aug 17.

Gene expression profiling reveals differential effects of sodium selenite, selenomethionine, and yeast-derived selenium in the mouse.

Genes & nutrition

Jamie L Barger, Tsuyoshi Kayo, Thomas D Pugh, James A Vann, Ronan Power, Karl Dawson, Richard Weindruch, Tomas A Prolla

Affiliations

  1. LifeGen Technologies, LLC, 510 Charmany Drive Suite 263, Madison, WI, 53719, USA, [email protected].

PMID: 21847681 PMCID: PMC3316740 DOI: 10.1007/s12263-011-0243-9

Abstract

The essential trace mineral selenium is an important determinant of oxidative stress susceptibility, with several studies showing an inverse relationship between selenium intake and cancer. Because different chemical forms of selenium have been reported to have varying bioactivity, there is a need for nutrigenomic studies that can comprehensively assess whether there are divergent effects at the molecular level. We examined the gene expression profiles associated with selenomethionine (SM), sodium selenite (SS), and yeast-derived selenium (YS) in the intestine, gastrocnemius, cerebral cortex, and liver of mice. Weanling mice were fed either a selenium-deficient (SD) diet (<0.01 mg/kg diet) or a diet supplemented with one of three selenium sources (1 mg/kg diet, as either SM, SS or YS) for 100 days. All forms of selenium were equally effective in activating standard measures of selenium status, including tissue selenium levels, expression of genes encoding selenoproteins (Gpx1 and Txnrd2), and increasing GPX1 enzyme activity. However, gene expression profiling revealed that SS and YS were similar (and distinct from SM) in both the expression pattern of individual genes and gene functional categories. Furthermore, only YS significantly reduced the expression of Gadd45b in all four tissues and also reduced GADD45B protein levels in liver. Taken together, these results show that gene expression profiling is a powerful technique capable of elucidating differences in the bioactivity of different forms of selenium.

References

  1. J Agric Food Chem. 2000 Jun;48(6):2062-70 - PubMed
  2. Oncogene. 2002 May 23;21(23):3663-9 - PubMed
  3. Int J Cancer. 2006 Apr 1;118(7):1777-81 - PubMed
  4. Mol Aspects Med. 2005 Aug-Oct;26(4-5):256-67 - PubMed
  5. BJU Int. 2003 May;91(7):608-12 - PubMed
  6. Exp Gerontol. 2008 Sep;43(9):859-66 - PubMed
  7. Antioxid Redox Signal. 2005 Mar-Apr;7(3-4):395-403 - PubMed
  8. Carcinogenesis. 2005 Jul;26(7):1256-62 - PubMed
  9. Neurobiol Dis. 2009 Jan;33(1):104-10 - PubMed
  10. J Anim Physiol Anim Nutr (Berl). 2010 Feb 1;94(1):99-110 - PubMed
  11. Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):804-10 - PubMed
  12. BMC Bioinformatics. 2005 Jun 08;6:144 - PubMed
  13. Biol Trace Elem Res. 2007 Apr;116(1):91-102 - PubMed
  14. JAMA. 1996 Dec 25;276(24):1957-63 - PubMed
  15. Anal Chem. 2005 Jan 1;77(1):344-9 - PubMed
  16. Methods Mol Biol. 2010;647:37-74 - PubMed
  17. Free Radic Biol Med. 2009 Jun 1;46(11):1527-33 - PubMed
  18. Antioxid Redox Signal. 2011 Mar 15;14(6):1093-106 - PubMed
  19. Cancer Metastasis Rev. 2002;21(3-4):281-9 - PubMed
  20. J Natl Cancer Inst. 2003 Feb 5;95(3):237-41 - PubMed
  21. Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1302-6 - PubMed
  22. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14548-53 - PubMed
  23. Science. 1999 Aug 27;285(5432):1390-3 - PubMed
  24. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3633-8 - PubMed
  25. PLoS One. 2008 Jun 04;3(6):e2264 - PubMed
  26. JAMA. 2009 Jan 7;301(1):39-51 - PubMed
  27. J Assoc Off Anal Chem. 1983 Jul;66(4):918-26 - PubMed
  28. Proc Nutr Soc. 2005 Nov;64(4):527-42 - PubMed
  29. J Nutr. 2007 May;137(5):1338-40 - PubMed
  30. J Natl Cancer Inst. 2005 Jan 19;97(2):94-102 - PubMed
  31. J Cell Physiol. 2009 Jan;218(1):26-31 - PubMed
  32. Comp Biochem Physiol B Biochem Mol Biol. 2003 Dec;136(4):921-34 - PubMed
  33. Mol Nutr Food Res. 2009 Dec;53(12):1561-72 - PubMed
  34. Poult Sci. 2010 May;89(5):931-7 - PubMed
  35. J Nutr. 2001 Dec;131(12):3175-81 - PubMed
  36. J Trace Elem Med Biol. 2009;23(1):29-35 - PubMed

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