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Al-Jumaily U, Sammour I, Al-Muhaisen F, et al. Precocious puberty in an infant with hepatoblastoma: a case report. J Med Case Rep. 2011;5:422doi: 10.1186/1752-1947-5-422.
Al-Jumaily, U., Sammour, I., Al-Muhaisen, F., Ajlouni, F., & Sultan, I. (2011). Precocious puberty in an infant with hepatoblastoma: a case report. Journal of medical case reports, 5422. https://doi.org/10.1186/1752-1947-5-422
Al-Jumaily, Usama, et al. "Precocious puberty in an infant with hepatoblastoma: a case report." Journal of medical case reports vol. 5 (2011): 422. doi: https://doi.org/10.1186/1752-1947-5-422
Al-Jumaily U, Sammour I, Al-Muhaisen F, Ajlouni F, Sultan I. Precocious puberty in an infant with hepatoblastoma: a case report. J Med Case Rep. 2011 Aug 30;5:422. doi: 10.1186/1752-1947-5-422. PMID: 21878089; PMCID: PMC3171382.
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J Med Case Rep. 2011 Aug 30;5:422. doi: 10.1186/1752-1947-5-422.

Precocious puberty in an infant with hepatoblastoma: a case report.

Journal of medical case reports

Usama Al-Jumaily, Ibrahim Sammour, Fadi Al-Muhaisen, Fatenah Ajlouni, Iyad Sultan

Affiliations

  1. Department of Pediatric Oncology, King Hussein Cancer Center, Queen Rania Al Abdullah St, Amman, 11941, Jordan. [email protected].

PMID: 21878089 PMCID: PMC3171382 DOI: 10.1186/1752-1947-5-422

Abstract

INTRODUCTION: The syndrome of isosexual precocious puberty associated with primary malignant hepatic tumors is rare. All previously reported cases in the literature are old and prognosis was grim.

CASE PRESENTATION: We present the case of a 15-month-old Asian male baby who presented with precocious puberty associated with hepatoblastoma. Serum concentrations of alpha-fetoprotein and free testosterone were elevated, as was beta human chorionic gonadotropin hormone. He was treated with six courses of chemotherapy and underwent surgery. His surface markers as well as free testosterone level returned to normal during therapy. The child has now been off therapy for 18 months with no evidence of tumor recurrence at follow-up.

CONCLUSION: Virilizing hepatoblastoma is rare and reported with poor outcome, but the development of new chemotherapeutic agents and complete surgical resection are promising.

References

  1. Acta Paediatr Scand. 1978 May;67(3):389-92 - PubMed
  2. J Pediatr Endocrinol Metab. 2008 Mar;21(3):275-7 - PubMed
  3. J Clin Pathol. 1984 Jul;37(7):734-7 - PubMed
  4. Eur J Pediatr. 1988 Jun;147(5):514-5 - PubMed
  5. Cancer. 1985 Oct 1;56(7):1636-42 - PubMed
  6. Cancer. 1983 May 1;51(9):1647-52 - PubMed
  7. Cancer. 1985 Oct 1;56(7):1725-9 - PubMed
  8. Rev Invest Clin. 1979 Jul-Sep;31(3):251-5 - PubMed
  9. CA Cancer J Clin. 1982 Sep-Oct;32(5):293-300 - PubMed
  10. Eur J Pediatr. 1981 Feb;135(3):313-7 - PubMed
  11. Helv Paediatr Acta. 1980 May;35(2):155-63 - PubMed
  12. J Pediatr Surg. 1985 Dec;20(6):713-4 - PubMed
  13. J Pediatr Surg. 1987 May;22(5):406-11 - PubMed
  14. Stem Cells. 1998;16(5):329-33 - PubMed
  15. J Clin Endocrinol Metab. 1972 Dec;35(6):857-62 - PubMed

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