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Tauriainen E, Luostarinen M, Martonen E, et al. Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation. J Nutr Metab. 2011;2011:525094doi: 10.1155/2011/525094.
Tauriainen, E., Luostarinen, M., Martonen, E., Finckenberg, P., Kovalainen, M., Huotari, A., Herzig, K. H., Lecklin, A., & Mervaala, E. (2011). Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation. Journal of nutrition and metabolism, 2011525094. https://doi.org/10.1155/2011/525094
Tauriainen, Eveliina, et al. "Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation." Journal of nutrition and metabolism vol. 2011 (2011): 525094. doi: https://doi.org/10.1155/2011/525094
Tauriainen E, Luostarinen M, Martonen E, Finckenberg P, Kovalainen M, Huotari A, Herzig KH, Lecklin A, Mervaala E. Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation. J Nutr Metab. 2011;2011:525094. doi: 10.1155/2011/525094. Epub 2011 Oct 01. PMID: 21977315; PMCID: PMC3184417.
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J Nutr Metab. 2011;2011:525094. doi: 10.1155/2011/525094. Epub 2011 Oct 01.

Distinct effects of calorie restriction and resveratrol on diet-induced obesity and Fatty liver formation.

Journal of nutrition and metabolism

Eveliina Tauriainen, Mira Luostarinen, Essi Martonen, Piet Finckenberg, Miia Kovalainen, Anne Huotari, Karl-Heinz Herzig, Anne Lecklin, Eero Mervaala

Affiliations

  1. Institute of Biomedicine, Pharmacology, University of Helsinki, Biomedicum Helsinki, P.O. Box 63, 00014 Helsinki, Finland.

PMID: 21977315 PMCID: PMC3184417 DOI: 10.1155/2011/525094

Abstract

The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated. We compared the effects of both CR (70% of ad libitum energy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl/6J mice, and we examined their effects on calorimetry, metabolic performance, and the expressions of inflammatory genes and SIRT proteins. We found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle SIRT1 and SIRT4 expression while other examined parameter were unaffected by resveratrol. In contrast, CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation. CR increased expressions of SIRT3 in metabolically important tissues, suggesting that the beneficial effects of CR are mediated, at least in part, via SIRT3-dependent pathways.

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