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Song M, Guo D, Pan C, et al. The application of poly(N-isopropylacrylamide)-co-polystyrene nanofibers as an additive agent to facilitate the cellular uptake of an anticancer drug. Nanotechnology. 2008;19(16):165102doi: 10.1088/0957-4484/19/16/165102.
Song, M., Guo, D., Pan, C., Jiang, H., Chen, C., Zhang, R., Gu, Z., & Wang, X. (2008). The application of poly(N-isopropylacrylamide)-co-polystyrene nanofibers as an additive agent to facilitate the cellular uptake of an anticancer drug. Nanotechnology, 19(16), 165102. https://doi.org/10.1088/0957-4484/19/16/165102
Song, Min, et al. "The application of poly(N-isopropylacrylamide)-co-polystyrene nanofibers as an additive agent to facilitate the cellular uptake of an anticancer drug." Nanotechnology vol. 19,16 (2008): 165102. doi: https://doi.org/10.1088/0957-4484/19/16/165102
Song M, Guo D, Pan C, Jiang H, Chen C, Zhang R, Gu Z, Wang X. The application of poly(N-isopropylacrylamide)-co-polystyrene nanofibers as an additive agent to facilitate the cellular uptake of an anticancer drug. Nanotechnology. 2008 Apr 23;19(16):165102. doi: 10.1088/0957-4484/19/16/165102. Epub 2008 Mar 18. PMID: 21825633.
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Nanotechnology. 2008 Apr 23;19(16):165102. doi: 10.1088/0957-4484/19/16/165102. Epub 2008 Mar 18.

The application of poly(N-isopropylacrylamide)-co-polystyrene nanofibers as an additive agent to facilitate the cellular uptake of an anticancer drug.

Nanotechnology

Min Song, Dadong Guo, Chao Pan, Hui Jiang, Chen Chen, Renyun Zhang, Zhongze Gu, Xuemei Wang

Affiliations

  1. State Key Lab of Bioelectronics, Chien-Shiung Wu Laboratory, Southeast University, Nanjing 210096, People's Republic of China.

PMID: 21825633 DOI: 10.1088/0957-4484/19/16/165102

Abstract

In this paper, we have fabricated poly(N-isopropylacrylamide)-co-polystyrene (PNIPAM-co-PS) nanofibers by electrospinning and explored the possibility to utilize the PNIPAM-co-PS nanofibers to enhance the permeation and uptake of the anticancer drug daunorubicin in drug-sensitive and drug-resistant leukemia K562 cells. Our MTT assay and electrochemical studies demonstrate that PNIPAM-co-PS nanofibers could play an important role in facilitating the cell track and drug delivery to the cancer cells. Meanwhile, the observations of atomic force microscopy (AFM) and confocal fluorescence microscopy indicate that the relevant interaction of the PNIPAM-co-PS nanofibers with bioactive molecules on the membrane of leukemia cell lines could affect the intracellular drug uptake positively and lead to the efficient accumulation of daunorubicin in drug-sensitive and drug-resistant cancer cells.

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